dc.creator | Phelan, Jody E | |
dc.creator | Coll, Francesc | |
dc.creator | Bergval, Indra | |
dc.creator | Anthony, Richard M | |
dc.creator | Warren, Rob | |
dc.creator | Sampson, Samantha L | |
dc.creator | Gey van Pittius, Nicolaas C | |
dc.creator | Glynn, Judith R | |
dc.creator | Crampin, Amelia C | |
dc.creator | Alves, Adriana | |
dc.creator | Bessa, Theolis Costa Barbosa | |
dc.creator | Campino, Susana | |
dc.creator | Dheda, Keertan | |
dc.creator | Grandjean, Louis | |
dc.creator | Hasan, Rumina | |
dc.creator | Hasan, Zahra | |
dc.creator | Miranda, Anabela | |
dc.creator | Moore, David | |
dc.creator | Panaiotov, Stefan | |
dc.creator | Perdigao, Joao | |
dc.creator | Portugal, Isabel | |
dc.creator | Sheen, Patricia | |
dc.creator | Sousa, Erivelton de Oliveira | |
dc.creator | Streicher, Elizabeth M | |
dc.creator | van Helden, Paul D | |
dc.creator | Viveiros, Miguel | |
dc.creator | Hibberd, Martin L | |
dc.creator | Pain, Arnab | |
dc.creator | McNerney, Ruth | |
dc.creator | Clark, Taane G | |
dc.date | 2017-02-10T16:54:31Z | |
dc.date | 2017-02-10T16:54:31Z | |
dc.date | 2016 | |
dc.date.accessioned | 2023-09-26T23:24:18Z | |
dc.date.available | 2023-09-26T23:24:18Z | |
dc.identifier | PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016. | |
dc.identifier | 1471-2164 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/17788 | |
dc.identifier | 10.1186/s12864-016-2467-y | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8890215 | |
dc.description | Biotechnology and Biological Sciences Research Council | |
dc.description | Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | BioMed Central | |
dc.rights | open access | |
dc.subject | Mycobacterium tuberculosis | |
dc.subject | Genoma, Bacteriano | |
dc.subject | Genomica | |
dc.subject | Evolução, Molecular | |
dc.subject | DNA, Bacteriana | |
dc.subject | Análise de Seqüência, DNA | |
dc.subject | Genes, Bacteriana | |
dc.subject | Mycobacterium tuberculosis | |
dc.subject | Genome, Bacterial | |
dc.subject | Genomics | |
dc.subject | Evolution, Molecular | |
dc.subject | DNA, Bacterial | |
dc.subject | Sequence Analysis, DNA | |
dc.subject | Genes, Bacteriano | |
dc.title | Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages | |
dc.type | Article | |