Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

dc.creatorPhelan, Jody E
dc.creatorColl, Francesc
dc.creatorBergval, Indra
dc.creatorAnthony, Richard M
dc.creatorWarren, Rob
dc.creatorSampson, Samantha L
dc.creatorGey van Pittius, Nicolaas C
dc.creatorGlynn, Judith R
dc.creatorCrampin, Amelia C
dc.creatorAlves, Adriana
dc.creatorBessa, Theolis Costa Barbosa
dc.creatorCampino, Susana
dc.creatorDheda, Keertan
dc.creatorGrandjean, Louis
dc.creatorHasan, Rumina
dc.creatorHasan, Zahra
dc.creatorMiranda, Anabela
dc.creatorMoore, David
dc.creatorPanaiotov, Stefan
dc.creatorPerdigao, Joao
dc.creatorPortugal, Isabel
dc.creatorSheen, Patricia
dc.creatorSousa, Erivelton de Oliveira
dc.creatorStreicher, Elizabeth M
dc.creatorvan Helden, Paul D
dc.creatorViveiros, Miguel
dc.creatorHibberd, Martin L
dc.creatorPain, Arnab
dc.creatorMcNerney, Ruth
dc.creatorClark, Taane G
dc.date2017-02-10T16:54:31Z
dc.date2017-02-10T16:54:31Z
dc.date2016
dc.date.accessioned2023-09-26T23:24:18Z
dc.date.available2023-09-26T23:24:18Z
dc.identifierPHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016.
dc.identifier1471-2164
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17788
dc.identifier10.1186/s12864-016-2467-y
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890215
dc.descriptionBiotechnology and Biological Sciences Research Council
dc.descriptionApproximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectMycobacterium tuberculosis
dc.subjectGenoma, Bacteriano
dc.subjectGenomica
dc.subjectEvolução, Molecular
dc.subjectDNA, Bacteriana
dc.subjectAnálise de Seqüência, DNA
dc.subjectGenes, Bacteriana
dc.subjectMycobacterium tuberculosis
dc.subjectGenome, Bacterial
dc.subjectGenomics
dc.subjectEvolution, Molecular
dc.subjectDNA, Bacterial
dc.subjectSequence Analysis, DNA
dc.subjectGenes, Bacteriano
dc.titleRecombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
dc.typeArticle


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