Article
Immunosuppressants: Implications in Orthodontics
Registro en:
SANTOS, R. L. et al. Immunosuppressants: Implications in Orthodontics. Dental Press J Orthod., v.17, n.2, p.55-61, Mar-Apr. 2012.
2176-9451
2177-6709
Autor
Santos, Rogério Lacerda dos
Lacerda, Maria Cláudia Mesquita
Gonçalves, Renato Torres
Martins, Marco Aurélio
Souza, Margareth Maria Gomes de
Resumen
Introduction: There are medications capable of affecting bone metabolism and the rate of tooth movement.
Among these medications are the immunosuppressants, which act by repressing the action of T lymphocytes, however
they can cause bone loss and consequently lead to osteoporosis. Osteoporosis is a common complication following
kidney, heart, liver or lung transplantation. The immunosuppressant treatment for preventing organ rejection
after transplantation, in general, includes glucocorticoids, cyclosporine, tacrolimus, and sirolimus. All these
drugs can have jeopardizing effects on bone mineral homeostasis and consequently influence tooth movement. In
recent years, however, the increasing use of immunosuppressants has raised questions about their effects on bone
metabolism in patients undergoing orthodontic treatment.
Objective: The objective of this review study was to inform orthodontists about the influence of immunosuppressants
on bone metabolism and tooth movement.