Article
Absence of strong linkage disequilibrium between odorant receptor alleles and the major histocompatibility complex
Registro en:
SILVA, José Samuel da et al. Absence of strong linkage disequilibrium between odorant receptor alleles and the major histocompatibility complex. Human Immunology, v. 74, p. 1619–1623, 2013.
0198-8859
10.1016/j.humimm.2013.08.005
Autor
Silva, José Samuel da
Wowk, Pryscilla Fanini
Poerner, Fabiana
Santos, Pablo Sandro Carvalho
Bicalho, Maria da Graça
Resumen
The odorant receptor (OR) genes constitute the largest gene family among vertebrates. While over 800 loci are present in the human genome, their allele diversity is still poorly characterized. It has been
hypothesized that the products of OR genes can be relevant in the reproductive context, thereby interacting with products of genes of the major histocompatibility complex (MHC). Here we investigated the
genetic diversity of the OR2W6P, OR2B8P, OR1F12 and OR12D2 genes, in order to define haplotypes and haplotype frequencies. We measured levels of linkage disequilibrium (LD) between these OR genes
and the MHC genes HLA-A, HLA-B and HLA-DRB1. This was accomplished through the assessment of 30 single nucleotide polymorphisms (SNPs) in samples from 61 family trios. We characterized 26 alleles
among the four OR genes and identified three SNPs that had not yet been reported. Based on our haplotype analysis, LD spanning the OR-HLA region is not very strong, and therefore not enough to enable
selection regarding specific HLA-OR haplotypes.