Absence of strong linkage disequilibrium between odorant receptor alleles and the major histocompatibility complex

dc.creatorSilva, José Samuel da
dc.creatorWowk, Pryscilla Fanini
dc.creatorPoerner, Fabiana
dc.creatorSantos, Pablo Sandro Carvalho
dc.creatorBicalho, Maria da Graça
dc.date2016-10-07T17:49:53Z
dc.date2016-10-07T17:49:53Z
dc.date2013
dc.date.accessioned2023-09-26T22:53:31Z
dc.date.available2023-09-26T22:53:31Z
dc.identifierSILVA, José Samuel da et al. Absence of strong linkage disequilibrium between odorant receptor alleles and the major histocompatibility complex. Human Immunology, v. 74, p. 1619–1623, 2013.
dc.identifier0198-8859
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16149
dc.identifier10.1016/j.humimm.2013.08.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884438
dc.descriptionThe odorant receptor (OR) genes constitute the largest gene family among vertebrates. While over 800 loci are present in the human genome, their allele diversity is still poorly characterized. It has been hypothesized that the products of OR genes can be relevant in the reproductive context, thereby interacting with products of genes of the major histocompatibility complex (MHC). Here we investigated the genetic diversity of the OR2W6P, OR2B8P, OR1F12 and OR12D2 genes, in order to define haplotypes and haplotype frequencies. We measured levels of linkage disequilibrium (LD) between these OR genes and the MHC genes HLA-A, HLA-B and HLA-DRB1. This was accomplished through the assessment of 30 single nucleotide polymorphisms (SNPs) in samples from 61 family trios. We characterized 26 alleles among the four OR genes and identified three SNPs that had not yet been reported. Based on our haplotype analysis, LD spanning the OR-HLA region is not very strong, and therefore not enough to enable selection regarding specific HLA-OR haplotypes.
dc.formatapplication/pdf
dc.languagepor
dc.rightsrestricted access
dc.subjectGenoma Humano
dc.subjectGenetic Variation
dc.subjectMajor Histocompatibility Complex
dc.subjectVariación Genética
dc.subjectComplejo Mayor de Histocompatibilidad
dc.subjectGenes
dc.subjectVariação Genética
dc.subjectComplexo Principal de Histocompatibilidade
dc.titleAbsence of strong linkage disequilibrium between odorant receptor alleles and the major histocompatibility complex
dc.typeArticle


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