Article
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
Registro en:
FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020.
1662-4025
10.1159/000505666
1662-4033
Autor
Fonseca, Ana Carolina Proença da
Fonseca, Guilherme Proença da
Marchesini, Bruna
Voigt, Danielle Dutra
Campos Junior, Mario
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernán
Cabello, Giselda Maria Kalil
Resumen
Regular physical activity has an important role in energy expenditure and combats the development of obesity. During exercise, PPARGC1A is overexpressed, stimulating an
increase of the expression of FNDC5. This protein is cleaved to release the hormone irisin,
which activates a browning process in white adipose tissue through an increase in UCP1 expression. As a result, irisin leads to mitochondrial heat production and energy expenditure.