Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity

dc.creatorFonseca, Ana Carolina Proença da
dc.creatorFonseca, Guilherme Proença da
dc.creatorMarchesini, Bruna
dc.creatorVoigt, Danielle Dutra
dc.creatorCampos Junior, Mario
dc.creatorZembrzuski, Verônica Marques
dc.creatorCarneiro, João Regis Ivar
dc.creatorNogueira Neto, José Firmino
dc.creatorCabello, Pedro Hernán
dc.creatorCabello, Giselda Maria Kalil
dc.date2020-07-02T19:31:01Z
dc.date2020-07-02T19:31:01Z
dc.date2020
dc.date.accessioned2023-09-26T22:28:08Z
dc.date.available2023-09-26T22:28:08Z
dc.identifierFONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020.
dc.identifier1662-4025
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42050
dc.identifier10.1159/000505666
dc.identifier1662-4033
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8879623
dc.descriptionRegular physical activity has an important role in energy expenditure and combats the development of obesity. During exercise, PPARGC1A is overexpressed, stimulating an increase of the expression of FNDC5. This protein is cleaved to release the hormone irisin, which activates a browning process in white adipose tissue through an increase in UCP1 expression. As a result, irisin leads to mitochondrial heat production and energy expenditure.
dc.formatapplication/pdf
dc.languageeng
dc.publisherS. Karger AG, Basel
dc.rightsopen access
dc.subjectVariantes genéticas
dc.subjectObesidade grave
dc.subjectVia adipocitária
dc.subjectRisco
dc.subjectSevere Obesity
dc.subjectGenetic Variants
dc.subjectAdipocyte Pathway
dc.subjectRisk
dc.titleGenetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
dc.typeArticle


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