Article
Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice.
Registro en:
LONGO, B. et al. Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice. Epilepsia, v. 51, n. 8, p. 1628-1632, 2010.
1528-1167
10.1111/j.1528-1167.2010.02570.x
Autor
Longo, Beatriz Monteiro
Romariz, Simone
Blanco, Miriam Marcela
Vasconcelos, Juliana Fraga
Bahia, Luciana
Soares, Milena Botelho Pereira
Mello, Luiz Eugenio Araujo de Morais
Santos, Ricardo Ribeiro dos
Resumen
The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epiepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP(+) bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. The pattern of distribution, proliferation, and differentiation of GFP(+)cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.