Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice.

dc.creatorLongo, Beatriz Monteiro
dc.creatorRomariz, Simone
dc.creatorBlanco, Miriam Marcela
dc.creatorVasconcelos, Juliana Fraga
dc.creatorBahia, Luciana
dc.creatorSoares, Milena Botelho Pereira
dc.creatorMello, Luiz Eugenio Araujo de Morais
dc.creatorSantos, Ricardo Ribeiro dos
dc.date2014-11-28T13:25:28Z
dc.date2014-11-28T13:25:28Z
dc.date2010
dc.date.accessioned2023-09-26T22:07:58Z
dc.date.available2023-09-26T22:07:58Z
dc.identifierLONGO, B. et al. Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice. Epilepsia, v. 51, n. 8, p. 1628-1632, 2010.
dc.identifier1528-1167
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8998
dc.identifier10.1111/j.1528-1167.2010.02570.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8875190
dc.descriptionThe distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epiepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP(+) bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. The pattern of distribution, proliferation, and differentiation of GFP(+)cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley Periodicals, Inc
dc.rightsopen access
dc.subjectHippocampus
dc.subjectChimeric mice
dc.subjectMicroglia
dc.subjectStatus epilepticus
dc.subjectGFP
dc.subjectCélulas da Medula Óssea/fisiologia
dc.subjectTransplante de Medula Óssea/métodos
dc.subjectEncéfalo/cirurgia
dc.subjectProliferação de Células
dc.subjectEstado Epiléptico/cirurgia
dc.subjectAnimais
dc.subjectEncéfalo/patologia
dc.subjectBromodesoxiuridina/metabolismo
dc.subjectContagem de Células/métodos
dc.subjectModelos Animais de Doenças
dc.subjectProteínas de Fluorescência Verde/genética
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos C57BL
dc.subjectProteínas do Tecido Nervoso/metabolismo
dc.subjectEstado Epiléptico/induzido quimicamente
dc.titleDistribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice.
dc.typeArticle


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