Article
Phagocytosis is inhibited by autophagic induction in murine macrophages.
Registro en:
LIMA, J. G. B. et al. Phagocytosis is inhibited by autophagic induction in murine macrophages. Biochemical and Biophysical Research Communications, v. 405, n. 4, p. 604-609, 2011.
1090-2104
10.1016/j.bbrc.2011.01.076
Autor
Lima, José Geraldo Bomfim
Vinhas, Christiana de Freitas
Gomes, Ivana Nunes
Azevedo, Carine Machado
Santos, Ricardo Ribeiro dos
Santos, Marcos André Vannier dos
Veras, Patrícia Sampaio Tavares
Resumen
Recent studies have demonstrated that communication takes place between the autophagic and phagocytic
pathways, indicating that the convergence of these two pathways plays an important role in the
innate immune response against intracellular microbes. The present study investigated the effect of autophagic
induction on the phagocytic capacity of murine macrophages. Autophagy induced by physiological
and pharmacological means was shown to reduce the phagocytic capacity of murine macrophages,
regardless of cell origin or the nature of the phagocytosed particles themselves. This autophagic inhibitory
effect on phagocytosis was shown to be an early and reversible event that results in no loss of cell
viability. Furthermore, the data presented herein demonstrate that the induction of autophagy does not
affect a macrophage’s capacity to recognize and bind to particles, indicating that autophagy does not inhibit
the particle recognition process, even though particle internalization is suppressed. The findings
herein support the notion that phagocytosis and autophagy may be interdependent and complementary
processes