Article
Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study.
Registro en:
GURGEL, C. A. S. et al. Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study. Journal of Molecular Histology, v. 39, n. 3, p. 311-316, 2008.
1567-2379
10.1007/s10735-008-9167-0
Autor
Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Azevedo, Roberto Almeida de
Sarmento, Viviane Almeida
Carvalho, Ana Maria da Silva
Santos, Jean Nunes dos
Resumen
Abstract Aim To investigate the immunohistochemical
expression of Ki-67, p53 and p63 in Keratocyst Odontogenic
Tumours (KOTs) in order to contribute to the
biological profile of this tumor. Methods Immunohistochemical
technique was performed using the EnVisionTM
System in 37 cases of KOTs. Results Ki-67- and p53-
immunostained cells were mainly located in the suprabasal
layers. p63-positive cells were found throughout the lining
cystic epithelium. No difference in the immunostaining for
these proteins was observed between primary and recurrent
KOTs (Ki-67: P = 0.5591; p53: P = 0.9847; p63:
P = 0.9127), or between KOTs associated with Nevoid
Basal Cell Carcinoma Syndrome (NBCCS) and sporadic
KOTs (Ki-67: P = 0.7013; p53: P = 0.3197; p63:
P = 0.2427). Conclusions It is possible that biological
behavior of KOTs may be related to suprabasal proliferative
compartment in the cystic epithelium as observed by
high levels of Ki-67, p53 and p63. In addition, p63
immunostaining may represent immaturity of keratinocytes
in KOTs, and suggests that this protein may participate in
the regulation of epithelial cell differentiation. Taken
together, these data may favor tumorigenesis on KOTs.
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