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| Article
Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
Registro en:
BADARÓ, R. Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: a literature review. Journal of the InternationalAssociation of Providers of AIDS Care, p. 1-6, 2014.
2325-9574
10.1177/2325957414555225
Autor
Badaró, Roberto José da Silva
Gonçalves, Larissa Oliveira
Gois, Luana Leandro
Maia, Zuinara Pereira Gusmão
Benson, Constance
Grassi, Maria Fernanda Rios
Resumen
Introduction: After the onset of highly active antiretroviral therapy (HAART), some HIV-infected patients present a severe
inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory
syndrome (IRIS). Few reports of tegumentary and visceral leishmaniasis have been described in association with IRIS.
Methods: A systematic literature review of IRIS in association with leishmaniasis identified 34 reported cases. Results and
Discussion: The majority of these occurred in males 4 months following the onset of HAART. The mean CD4 count before
HAART was 94 + 77 cells/mm3, increasing to 5 times the initial value between the onset of HAART and IRIS presentation.
Visceral leishmaniasis and post–kala-azar dermal leishmaniasis were the most commonly reported clinical manifestations, followed
by tegumentary leishmaniasis and uveitis. Conclusions: Commonly found characteristics included cutaneous involvement,
regardless of Leishmania species; appearance of lesions unrelated to time of probable Leishmania infection; rapid recovery of
CD4 count following HAART; and rapid progression.