Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review

dc.creatorBadaró, Roberto José da Silva
dc.creatorGonçalves, Larissa Oliveira
dc.creatorGois, Luana Leandro
dc.creatorMaia, Zuinara Pereira Gusmão
dc.creatorBenson, Constance
dc.creatorGrassi, Maria Fernanda Rios
dc.date2014-11-12T19:24:15Z
dc.date2014-11-12T19:24:15Z
dc.date2014
dc.date.accessioned2023-09-26T20:45:59Z
dc.date.available2023-09-26T20:45:59Z
dc.identifierBADARÓ, R. Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: a literature review. Journal of the InternationalAssociation of Providers of AIDS Care, p. 1-6, 2014.
dc.identifier2325-9574
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8818
dc.identifier10.1177/2325957414555225
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863491
dc.descriptionIntroduction: After the onset of highly active antiretroviral therapy (HAART), some HIV-infected patients present a severe inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory syndrome (IRIS). Few reports of tegumentary and visceral leishmaniasis have been described in association with IRIS. Methods: A systematic literature review of IRIS in association with leishmaniasis identified 34 reported cases. Results and Discussion: The majority of these occurred in males 4 months following the onset of HAART. The mean CD4 count before HAART was 94 + 77 cells/mm3, increasing to 5 times the initial value between the onset of HAART and IRIS presentation. Visceral leishmaniasis and post–kala-azar dermal leishmaniasis were the most commonly reported clinical manifestations, followed by tegumentary leishmaniasis and uveitis. Conclusions: Commonly found characteristics included cutaneous involvement, regardless of Leishmania species; appearance of lesions unrelated to time of probable Leishmania infection; rapid recovery of CD4 count following HAART; and rapid progression.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSage Publications
dc.rightsopen access
dc.subjectHIV/AIDS
dc.subjectImmune reconstitution inflammatory syndrome
dc.subjectIRIS
dc.subjectLeishmaniasis
dc.subjectCo-infection HIV/Leishmania
dc.titleLeishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
dc.typeArticle


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