Article
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
Registro en:
CRUZ, Daniella Arêas Mendes da; et al. Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors. Plos One, v.9, n.7, 7p, 2014.
10.1371/journal.pone.0103405
Autor
Cruz, Daniella Arêas Mendes da
Brignier, Anne Colette
Asnafi, Vahid
Beleydier, Frederic
Messias, Carolina Valença
Lepelletier, Yves
Bedjaoui, Nawel
Renand, Amedée
Smaniotto, Salete
Canloni, Danielle
Milpied, Pierre
Balabanian, Karl
Bousso, Phillippe
Leprétre, Stéphane
Bertrand, Yves
Dombret, Hervé
Ifrah, Norbert
Dardenne, Mireille
Macintyre, Elizabeth
Savino, Wilson
Hermine, Olivier
Resumen
Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the
developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we
describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell
precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments.
SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced
thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed
in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their
migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte
migration in physiological and pathological conditions.