Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors

dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorBrignier, Anne Colette
dc.creatorAsnafi, Vahid
dc.creatorBeleydier, Frederic
dc.creatorMessias, Carolina Valença
dc.creatorLepelletier, Yves
dc.creatorBedjaoui, Nawel
dc.creatorRenand, Amedée
dc.creatorSmaniotto, Salete
dc.creatorCanloni, Danielle
dc.creatorMilpied, Pierre
dc.creatorBalabanian, Karl
dc.creatorBousso, Phillippe
dc.creatorLeprétre, Stéphane
dc.creatorBertrand, Yves
dc.creatorDombret, Hervé
dc.creatorIfrah, Norbert
dc.creatorDardenne, Mireille
dc.creatorMacintyre, Elizabeth
dc.creatorSavino, Wilson
dc.creatorHermine, Olivier
dc.date2015-06-08T14:01:46Z
dc.date2015-06-08T14:01:46Z
dc.date2014
dc.date.accessioned2023-09-26T20:37:05Z
dc.date.available2023-09-26T20:37:05Z
dc.identifierCRUZ, Daniella Arêas Mendes da; et al. Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors. Plos One, v.9, n.7, 7p, 2014.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10675
dc.identifier10.1371/journal.pone.0103405
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860671
dc.descriptionNeuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPlos One
dc.rightsopen access
dc.subjectThymus
dc.subjectNeuropillins
dc.subjectSemaphorins
dc.subjectLymphoma
dc.subjectLeukemia
dc.subjectHuman T-Cell Precursors
dc.subjectNeuropilinas
dc.subjectSemaforinas
dc.subjectLeucemia
dc.subjectLinfoma
dc.titleSemaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
dc.typeArticle


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