Article
Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity
Registration in:
CRUZ, L. A. B.; BARRAL NETTO, M.; ANDRADE, B. B. Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity. PLoS Neglected Tropical Diseases, v. 12, n. 3), e0006306, 2018.
PLoS Neglected Tropical Diseases
10.1371/journal.pntd.0006306
Author
Cruz, Luís Antonio Bahiana
Barral Netto, Manoel
Andrade, Bruno de Bezerril
Abstract
Financiadora de Estudos e Projetos (FINEP) (grant Ward number: 010409605)/ Fundo Nacional de
Desenvolvimento Científico e Tecnológico (FNDCT-CT-Amazonia). MB-N is a senior investigator from
the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. LABC
received a fellowship from CNPq (154872/2017-2). Although Plasmodium vivax infection is a frequent cause of malaria worldwide, severe presentations have been more regularly described only in recent years. In this setting, despite clinical descriptions of multi-organ involvement, data associating it with kidney dysfunction are relatively scarce. Here, renal dysfunction is retrospectively analyzed in a large cohort of vivax malaria patients with an attempt to dissect its association with disease severity and mortality, and to determine the role of inflammation in its progression.