Article
CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
Registro en:
MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005.
0074-0276
10.1590/S0074-02762005000900015
1678-8060
Autor
Marino, A. P. M. P.
Silva, A. A.
Santos, P. V. A.
Pinto, L. M. O.
Gazinelli, R. T.
Teixeira, M. M.
Lannes-Vieira, Joseli
Resumen
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1α, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzielicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.