CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis

dc.creatorMarino, A. P. M. P.
dc.creatorSilva, A. A.
dc.creatorSantos, P. V. A.
dc.creatorPinto, L. M. O.
dc.creatorGazinelli, R. T.
dc.creatorTeixeira, M. M.
dc.creatorLannes-Vieira, Joseli
dc.date2019-05-30T15:46:45Z
dc.date2019-05-30T15:46:45Z
dc.date2005
dc.date.accessioned2023-09-26T20:24:04Z
dc.date.available2023-09-26T20:24:04Z
dc.identifierMARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33296
dc.identifier10.1590/S0074-02762005000900015
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856085
dc.descriptionThe comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1α, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzielicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectMiocardite
dc.subjectQuimiocinas CC
dc.subjectReceptores de quimiocinas CC
dc.subjectTrypanosoma cruzi
dc.subjectMyocarditis
dc.subjectCC-chemokines
dc.subjectCC-chemokine receptors
dc.subjectMet-RANTES
dc.titleCC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
dc.typeArticle


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