Ministério da SaúdeBackground: Rapid response in health technology assessment is a synthesis of the best available evidence prepared in a timely manner to meet specific demands. We build a consensus among Brazilian specialists in health technology assessment to propose guidelines for the development of rapid response. Methods: Based on a systematic review that proposed eight methodological steps to conduct rapid response, we applied a modified Delphi technique (without open questions in the first round) to reach consensus among Brazilian experts in health technology assessment. Twenty participants were invited to judge the feasibility of each methodological step in a five-point Likert scale. Consensus was reached if the step had 70% positive approval or interquartile range ≤ 1. Results: The achievement of consensus was reached in the second round. Between the first and the second round, we scrutinized all points reported by the experts. The Delphi panel reached consensus of eight steps: definition of the structured question of rapid response (with a restricted scope); definition of the eligibility criteria for study types (preferably systematic reviews); search strategy (language and data limits) and sources of information (minimum two); selection of studies (independently by two responders); critical appraisal of the included studies and the risk of bias for the outcomes of interest; data extraction from the included articles; summary of evidence; and preparation of the report. Conclusions: The guidelines for rapid response in health technology assessment may help governments to make better decisions in a short period of time (35 days). The adoption of methodological processes should improve both the quality and consistency of health technology assessments of rapid decisions in the Brazilian setting.