Article
Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil
Registro en:
COSTA, Allyson Guimarães et al. Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil. Public Library of Science. Plos One, v. 12, n. 8, Aug. 2017.
1932-6203
10.1371/journal.pone.0183840
1932-6203
Autor
Costa, Allyson Guimarães
Ramasawmy, Rajendranath
Ibiapina, Hiochelson Najibe Santos
Sampaio, Vanderson Souza
Xábregas, Lilyane Amorim
Brasil, Larissa Wanderley
Tarragô, Andréa Monteiro
Almeida, Anne Cristine Gomes
Kuehn, Andréa
Vitor-Silva, Sheila
Melo, Gisely Cardoso
Siqueira, André Machado
Monteiro, Wuelton Marcelo
Lacerda, Marcus Vinicius Guimarães
Malheiro, Adriana
Resumen
Plasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset of the vector-parasite-host interaction through the binding of pathogen-associated molecular patterns (PAMPs) and receptors of innate immunity, such as toll-like receptors (TLRs). The triggering of the signaling cascade produces an elevated inflammatory response. Genetic polymorphisms in TLRs are involved in susceptibility or resistance to infection, and the identification of genes involved with Pv-malaria response is important to elucidate the pathogenesis of the disease and may contribute to the formulation of control and elimination tools.