Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil

dc.creatorCosta, Allyson Guimarães
dc.creatorRamasawmy, Rajendranath
dc.creatorIbiapina, Hiochelson Najibe Santos
dc.creatorSampaio, Vanderson Souza
dc.creatorXábregas, Lilyane Amorim
dc.creatorBrasil, Larissa Wanderley
dc.creatorTarragô, Andréa Monteiro
dc.creatorAlmeida, Anne Cristine Gomes
dc.creatorKuehn, Andréa
dc.creatorVitor-Silva, Sheila
dc.creatorMelo, Gisely Cardoso
dc.creatorSiqueira, André Machado
dc.creatorMonteiro, Wuelton Marcelo
dc.creatorLacerda, Marcus Vinicius Guimarães
dc.creatorMalheiro, Adriana
dc.date2019-01-28T13:52:13Z
dc.date2019-01-28T13:52:13Z
dc.date2017
dc.date.accessioned2023-09-26T20:19:33Z
dc.date.available2023-09-26T20:19:33Z
dc.identifierCOSTA, Allyson Guimarães et al. Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil. Public Library of Science. Plos One, v. 12, n. 8, Aug. 2017.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31324
dc.identifier10.1371/journal.pone.0183840
dc.identifier1932-6203
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854276
dc.descriptionPlasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset of the vector-parasite-host interaction through the binding of pathogen-associated molecular patterns (PAMPs) and receptors of innate immunity, such as toll-like receptors (TLRs). The triggering of the signaling cascade produces an elevated inflammatory response. Genetic polymorphisms in TLRs are involved in susceptibility or resistance to infection, and the identification of genes involved with Pv-malaria response is important to elucidate the pathogenesis of the disease and may contribute to the formulation of control and elimination tools.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectMalaria
dc.subjectPlasmodium vivax
dc.subjectTLR variants
dc.subjectParasitemia
dc.subjectAmazon Region
dc.subjectBrazil
dc.titleAssociation of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil
dc.typeArticle


Este ítem pertenece a la siguiente institución