Article
Synthesis and antimycobacterial activity of N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives
Registro en:
VERGARA, Fátima M. F. et al. Synthesis and antimycobacterial activity ofN0-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives. European Journal of Medicinal Chemistry, v. 44, n. 12, p. 4954-4959, 1 Sept. 2009.
0223-5234
10.1016/j.ejmech.2009.08.009
1768-3254
Autor
Vergara, Fátima M. F.
Lima, Camilo H. da S.
Henriques, Maria das Graças M. de O.
Candéa, André L. P.
Lourenço, Maria C. S.
Ferreira, Marcelle de L.
Kaiser, Carlos R.
Souza, Marcus V. N. de
Resumen
The present article describes a series of twenty-sixN0-[(E)-(monosubstituted-benzylidene)]-2-pyr-azinecarbohydrazide (4–29), which were synthesized and evaluated for their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette–Guerin (BCG). After-wards, the non-cytotoxic compounds (4, 6, 8, 15, 21, 23, 24, 27 and 28) were assessed against Myco-bacterium tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA) and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. The compounds 6, 23, 27 and 28 exhibited a significant activity (50–100mg/mL) when compared with first line drugs such as pyrazinamide and were not cytotoxic in their respective MIC values. 2023-01-07