Synthesis and antimycobacterial activity of N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives

dc.creatorVergara, Fátima M. F.
dc.creatorLima, Camilo H. da S.
dc.creatorHenriques, Maria das Graças M. de O.
dc.creatorCandéa, André L. P.
dc.creatorLourenço, Maria C. S.
dc.creatorFerreira, Marcelle de L.
dc.creatorKaiser, Carlos R.
dc.creatorSouza, Marcus V. N. de
dc.date2020-01-07T12:40:29Z
dc.date2020-01-07T12:40:29Z
dc.date2009
dc.date.accessioned2023-09-26T20:15:12Z
dc.date.available2023-09-26T20:15:12Z
dc.identifierVERGARA, Fátima M. F. et al. Synthesis and antimycobacterial activity ofN0-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives. European Journal of Medicinal Chemistry, v. 44, n. 12, p. 4954-4959, 1 Sept. 2009.
dc.identifier0223-5234
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39017
dc.identifier10.1016/j.ejmech.2009.08.009
dc.identifier1768-3254
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852527
dc.descriptionThe present article describes a series of twenty-sixN0-[(E)-(monosubstituted-benzylidene)]-2-pyr-azinecarbohydrazide (4–29), which were synthesized and evaluated for their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette–Guerin (BCG). After-wards, the non-cytotoxic compounds (4, 6, 8, 15, 21, 23, 24, 27 and 28) were assessed against Myco-bacterium tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA) and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. The compounds 6, 23, 27 and 28 exhibited a significant activity (50–100mg/mL) when compared with first line drugs such as pyrazinamide and were not cytotoxic in their respective MIC values.
dc.description2023-01-07
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectPyrazine
dc.subjectN-Acylhydrazones
dc.subjectAntimycobacterial activity
dc.subjectDrugs
dc.titleSynthesis and antimycobacterial activity of N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives
dc.typeArticle


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