Article
Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep
Registro en:
ZENG, Congli et al. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology, v. 133, n. 5, 17 p, Nov. 2020.
1528-1175
10.1097/ALN.0000000000003491
Autor
Zeng, Congli
Ribeiro, Gabriel C. Motta
Hinoshita, Takuga
Lessa, Marcos Adriano
Winkler, Tilo
Gorgg, Kira
Kingston, Nathan M.
Hutchinson, John N.
Sholl, Lynette Marie
Fang, Xiangming
Varelas, Xaralabos
Layne, Matthew D.
Baron, Rebecca M.
Melo, Marcos F. Vidal
Resumen
Pulmonary atelectasis is frequent in clinical settings. Yet there
is limited mechanistic understanding and substantial clinical and biologic contro versy on its consequences. The authors hypothesize that atelectasis produces local
transcriptomic changes related to immunity and alveolar–capillary barrier function
conducive to lung injury and further exacerbated by systemic inflammation. 2023