Article
Tuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil
Registro en:
GRASSI, M. F. R. et al. Tuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil. BMC Infectious Diseases, v. 16, p. 491, 2016.
1471-2334
10.1186/s12879-016-1428-z
Autor
Grassi, Maria Fernanda Rios
Santos, Normeide Pedreira dos
Lírio, Monique
Kritski, Afrânio Lineu
Almeida, Maria da Conceição Chagas de
Santana, Leonardo Pereira
Lázaro, Noilson
Dias, Juarez
Martins Netto, Eduardo
Castro Filho, Bernardo Galvão
Resumen
Few reports have investigated the association between human T-lymphotropic virus type 1 (HTLV-1) and tuberculosis (TB) in countries where both infections are endemic. This study estimates the incidence of TB in a cohort infected with HTLV-1, compared with non-infected individuals, over a ten-year period. Methods: Retrospective cohort study involving the cross-matching of records of individuals for whom a HTLV
serology was performed at a referral center for HTLV (CHTLV) with a database of TB cases from Sinan—the
Information System on Diseases of Compulsory Declaration between 2002 and 2012.
Results: From a cohort of 6,495 individuals, 1,711 were infected with HTLV-1. A total of 73 TB cases occurred during
the study period: 33 HTLV-1-infected patients and 40 uninfected individuals. The incidence density for TB in the
HTLV-1 infected group was 3.3 person-years per 1,000 individuals and 1.1 person-years per 1,000 individuals in the
group HTLV-1 uninfected group. The relative risk of developing TB in the group of patients infected with HTLV-1
was 2.6 (CI 95 % 1.6–4.2) in comparison with HTLV-1 uninfected group. Compared to individuals with isolated TB,
those in the HTLV-1 infected group who had TB were older (p = 0.005) and had lower education levels (p = 0.02).
No differences were observed with respect to the clinical/radiological presentation, nor in the outcome of TB and
prevalence of HIV infection, when comparing among the HTLV-1-infected and uninfected groups.
Conclusions: Patients infected with HTLV-1 are more susceptible to TB. The epidemiological characteristics of
HTLV-1/TB subjects and those infected with TB overlap.