Tuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil

dc.creatorGrassi, Maria Fernanda Rios
dc.creatorSantos, Normeide Pedreira dos
dc.creatorLírio, Monique
dc.creatorKritski, Afrânio Lineu
dc.creatorAlmeida, Maria da Conceição Chagas de
dc.creatorSantana, Leonardo Pereira
dc.creatorLázaro, Noilson
dc.creatorDias, Juarez
dc.creatorMartins Netto, Eduardo
dc.creatorCastro Filho, Bernardo Galvão
dc.date2016-12-13T16:49:19Z
dc.date2016-12-13T16:49:19Z
dc.date2016
dc.date.accessioned2023-09-26T20:11:06Z
dc.date.available2023-09-26T20:11:06Z
dc.identifierGRASSI, M. F. R. et al. Tuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil. BMC Infectious Diseases, v. 16, p. 491, 2016.
dc.identifier1471-2334
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16527
dc.identifier10.1186/s12879-016-1428-z
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850732
dc.descriptionFew reports have investigated the association between human T-lymphotropic virus type 1 (HTLV-1) and tuberculosis (TB) in countries where both infections are endemic. This study estimates the incidence of TB in a cohort infected with HTLV-1, compared with non-infected individuals, over a ten-year period. Methods: Retrospective cohort study involving the cross-matching of records of individuals for whom a HTLV serology was performed at a referral center for HTLV (CHTLV) with a database of TB cases from Sinan—the Information System on Diseases of Compulsory Declaration between 2002 and 2012. Results: From a cohort of 6,495 individuals, 1,711 were infected with HTLV-1. A total of 73 TB cases occurred during the study period: 33 HTLV-1-infected patients and 40 uninfected individuals. The incidence density for TB in the HTLV-1 infected group was 3.3 person-years per 1,000 individuals and 1.1 person-years per 1,000 individuals in the group HTLV-1 uninfected group. The relative risk of developing TB in the group of patients infected with HTLV-1 was 2.6 (CI 95 % 1.6–4.2) in comparison with HTLV-1 uninfected group. Compared to individuals with isolated TB, those in the HTLV-1 infected group who had TB were older (p = 0.005) and had lower education levels (p = 0.02). No differences were observed with respect to the clinical/radiological presentation, nor in the outcome of TB and prevalence of HIV infection, when comparing among the HTLV-1-infected and uninfected groups. Conclusions: Patients infected with HTLV-1 are more susceptible to TB. The epidemiological characteristics of HTLV-1/TB subjects and those infected with TB overlap.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectVírus T linfotrópico humano tipo 1
dc.subjectHTLV-1
dc.subjectTuberculose
dc.subjectIncidência
dc.subjectRisco relativo
dc.subjectHuman T-lymphotropic virus type 1
dc.subjectHTLV-1
dc.subjectTuberculosis
dc.subjectIncidence
dc.subjectRelative risk
dc.titleTuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil
dc.typeArticle


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