Article
Synthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives
Registro en:
REZENDE JÚNIOR, Celso de Oliveira et al. Synthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives. Chemical Biology and Drug Design, v. 86, n. 3, p. 344-350, Sept. 2015.
1747-0277
10.1111/cbdd.12498
Autor
Rezende Júnior, Celso de Oliveira
Oliveira, Larissa A.
Oliveira, Bruno A.
Almeida, Camila G.
Ferreira, Bianca S.
Le Hyaric, Mireille
Carvalho, Guilherme S. L.
Lourenço, Maria Cristina S.
Batista, Michel
Marchini, Fabrício Klerynton
Silva, Vania L.
Diniz, Claudio G.
Almeida, Mauro Vieira de
Resumen
FAPEMIG, CNPq, CAPES. Different series of N-alkylated diamines and their derivatives condensed to quinic acid were synthesized and tested for antibacterial properties against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The lipophilic chain and carbohydrate moiety modulate the antibacterial activity and the compounds showed a structure-activity relationship. Overall, 11 compounds displayed better activity than chloramphenicol against Gram-positive and Gram-negative bacteria. Monoalkylated amines 2a-h displayed an activity similar to that of ethambutol against Mycobacterium tuberculosis.