Synthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives

dc.creatorRezende Júnior, Celso de Oliveira
dc.creatorOliveira, Larissa A.
dc.creatorOliveira, Bruno A.
dc.creatorAlmeida, Camila G.
dc.creatorFerreira, Bianca S.
dc.creatorLe Hyaric, Mireille
dc.creatorCarvalho, Guilherme S. L.
dc.creatorLourenço, Maria Cristina S.
dc.creatorBatista, Michel
dc.creatorMarchini, Fabrício Klerynton
dc.creatorSilva, Vania L.
dc.creatorDiniz, Claudio G.
dc.creatorAlmeida, Mauro Vieira de
dc.date2016-10-05T19:10:45Z
dc.date2016-10-05T19:10:45Z
dc.date2015
dc.date.accessioned2023-09-26T20:06:23Z
dc.date.available2023-09-26T20:06:23Z
dc.identifierREZENDE JÚNIOR, Celso de Oliveira et al. Synthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives. Chemical Biology and Drug Design, v. 86, n. 3, p. 344-350, Sept. 2015.
dc.identifier1747-0277
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16107
dc.identifier10.1111/cbdd.12498
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8848606
dc.descriptionFAPEMIG, CNPq, CAPES.
dc.descriptionDifferent series of N-alkylated diamines and their derivatives condensed to quinic acid were synthesized and tested for antibacterial properties against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The lipophilic chain and carbohydrate moiety modulate the antibacterial activity and the compounds showed a structure-activity relationship. Overall, 11 compounds displayed better activity than chloramphenicol against Gram-positive and Gram-negative bacteria. Monoalkylated amines 2a-h displayed an activity similar to that of ethambutol against Mycobacterium tuberculosis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherDavid Selwood
dc.rightsrestricted access
dc.subjectAntibacterial
dc.subjectDiamines
dc.subjectLipophilicity
dc.subjectQuinic acid
dc.subjectTuberculosis
dc.titleSynthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives
dc.typeArticle


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