Abstract We apply different information quantifiers to the study of COVID-19 time series. First, we analyze how the fact of smoothing the curves alters the informational content of the series, by applying the permutation and wavelet entropies to the series of daily new cases using a sliding-window method. In addition, to study how coupled the curves associated with daily new cases of infections and deaths are, we compute the wavelet coherence. Our results show how information quantifiers can be used to analyze the unpredictable behavior of this pandemic in the short and medium terms.