A new kind of quinonic-antibiotic useful against multidrug-resistant S. aureus and E. faecium Infections

dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorUniversidad San Sebastián
dc.creatorCampanini-Salinas, Javier
dc.creatorAndrades-Lagos, Juan
dc.creatorRocha, Gerardo Gonzalez
dc.creatorChoquesillo-Lazarte, Duane
dc.creatorDragnic, Soledad Bollo
dc.creatorFaúndez, Mario
dc.creatorAlarcón, Pedro
dc.creatorSilva, Francisco
dc.creatorVidal, Roberto
dc.creatorSalas-Huenuleo, Edison
dc.creatorKogan, Marcelo
dc.creatorMella, Jaime
dc.creatorGajardo, Gonzalo Recabarren
dc.creatorVásquez-Velásquez, David
dc.date.accessioned2023-05-30T19:00:01Z
dc.date.accessioned2023-09-25T13:05:42Z
dc.date.available2023-05-30T19:00:01Z
dc.date.available2023-09-25T13:05:42Z
dc.date.created2023-05-30T19:00:01Z
dc.date.issued2018
dc.identifier1420-3049
dc.identifierhttps://repositorio.uss.cl/handle/uss/8205
dc.identifier10.3390/molecules23071776
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8805584
dc.description.abstractA rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained by a simple, two step synthesis and screened the products for in vitro antibacterial activity against ATCC® strains using the broth microdilution method. The compounds exhibited minimum inhibitory concentrations (MIC) of 1–32 µg/mL against Gram-positive ATCC® strains. The structure–activity relationship indicated that the thiophenol ring is essential for antibacterial activity and the substituents on the thiophenol ring module, for antibacterial activity.
dc.languageeng
dc.relationMolecules
dc.titleA new kind of quinonic-antibiotic useful against multidrug-resistant S. aureus and E. faecium Infections
dc.typeArtículo


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