preprint
Corticosteroids use and risk of respiratory coinfections in mechanically ventilated patients with COVID-19
Fecha
2021Registro en:
10.21203/rs.3.rs-966047/v1
Autor
Ceballos, María Elena
Núñez Palma, Carolina Verónica
Uribe, Javier
Vera Alarcón, María Magdalena
Castro López, Ricardo
García C., Patricia
Arriata, Gabriel
Gándara, Vicente
Vargas, Camila
Domínguez De Landa, María Angélica
Cerón, Inés
Born, Pablo
Espíndola, Eduardo
Institución
Resumen
Background: To describe respiratory coinfections, predictive factors and outcomes in patients requiring mechanical ventilation (MV) with COVID-19.
Methods: Cohort study, carried out in a Chilean single tertiary Hospital. All patients with COVID-19 admitted to ICU that required MV were included between 1 June and 31 July 2020
Results: 175 patients were admitted to ICU and required MV. Of these, 71 patients developed at least one respiratory coinfection (40.6 %). Early coinfections and late coinfections were diagnosed in 1.7% and 31.4% of all patients admitted to ICU respectively. Within late coinfections, 88% were bacterial, 10% were fungal, and 2% were viral coinfections. One third of isolated bacteria were multidrug-resistant. Multivariate analysis showed that the risk for coinfection was 7.7 times higher for patients with history of
corticosteroids (adOR = 7.65, CI 95%: 1.04-56.2, p=0,046) and 2.7 times higher for patients that received dexamethasone during hospitalization (adOR=2.69; CI 95%: 1.14-6.35, p=0,024) than patients that were not exposed. For each additional day in MV, the risk of coinfection increases 1.1 times (adOR=1.06; CI 95%: 1.01-1.11, p=0,025)