dc.creator | Ceballos, María Elena | |
dc.creator | Núñez Palma, Carolina Verónica | |
dc.creator | Uribe, Javier | |
dc.creator | Vera Alarcón, María Magdalena | |
dc.creator | Castro López, Ricardo | |
dc.creator | García C., Patricia | |
dc.creator | Arriata, Gabriel | |
dc.creator | Gándara, Vicente | |
dc.creator | Vargas, Camila | |
dc.creator | Domínguez De Landa, María Angélica | |
dc.creator | Cerón, Inés | |
dc.creator | Born, Pablo | |
dc.creator | Espíndola, Eduardo | |
dc.date.accessioned | 2023-06-06T20:51:40Z | |
dc.date.available | 2023-06-06T20:51:40Z | |
dc.date.created | 2023-06-06T20:51:40Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.21203/rs.3.rs-966047/v1 | |
dc.identifier | http://europepmc.org/abstract/PPR/PPR417067 | |
dc.identifier | https://repositorio.uc.cl/handle/11534/70532 | |
dc.description.abstract | Background: To describe respiratory coinfections, predictive factors and outcomes in patients requiring mechanical ventilation (MV) with COVID-19.
Methods: Cohort study, carried out in a Chilean single tertiary Hospital. All patients with COVID-19 admitted to ICU that required MV were included between 1 June and 31 July 2020
Results: 175 patients were admitted to ICU and required MV. Of these, 71 patients developed at least one respiratory coinfection (40.6 %). Early coinfections and late coinfections were diagnosed in 1.7% and 31.4% of all patients admitted to ICU respectively. Within late coinfections, 88% were bacterial, 10% were fungal, and 2% were viral coinfections. One third of isolated bacteria were multidrug-resistant. Multivariate analysis showed that the risk for coinfection was 7.7 times higher for patients with history of
corticosteroids (adOR = 7.65, CI 95%: 1.04-56.2, p=0,046) and 2.7 times higher for patients that received dexamethasone during hospitalization (adOR=2.69; CI 95%: 1.14-6.35, p=0,024) than patients that were not exposed. For each additional day in MV, the risk of coinfection increases 1.1 times (adOR=1.06; CI 95%: 1.01-1.11, p=0,025) | |
dc.language | en | |
dc.rights | Creative Commons Attribution 4.0 International License | |
dc.rights | acceso restringido | |
dc.subject | Coinfections | |
dc.subject | Secondary infections | |
dc.subject | COVID-19 | |
dc.subject | SARS-CoV-2 | |
dc.subject | ICU | |
dc.subject | Mechanical ventilation | |
dc.title | Corticosteroids use and risk of respiratory coinfections in mechanically ventilated patients with COVID-19 | |
dc.type | preprint | |