Artigo
PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach
Registro en:
Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 42, n. 3, p. 757-760, 2014.
1387-2877
10.3233/JAD-140033
WOS:000342237000004
Autor
Delabio, Roger
Rasmussen, Lucas
Mizumoto, Igor
Viani, Gustavo-Arruda
Chen, Elizabeth
Villares, Joao
Costa, Isabela-Bazzo
Turecki, Gustavo
Linde, Sandra Aparecido [UNESP]
Smith, Marilia Cardoso
Payao, Spencer-Luiz
Resumen
Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-beta peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Universidade do Sagrado Coracao de Bauru Faculdade de Medicina de Marilia (FAMEMA) Fac Med Marilia, Sao Paulo, Brazil Univ Sagrado Coracao, Sao Paulo, Brazil Univ Fed Sao Paulo, Sao Paulo, Brazil Douglas Hosp, Brain Bank, Montreal, PQ, Canada Univ Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo, Brazil Univ Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo, Brazil FAPESP: 09/10777-7 FAPESP: 09/15857-9