PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach

dc.contributorFac Med Marilia
dc.contributorUniv Sagrado Coracao
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorDouglas Hosp
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorDelabio, Roger
dc.creatorRasmussen, Lucas
dc.creatorMizumoto, Igor
dc.creatorViani, Gustavo-Arruda
dc.creatorChen, Elizabeth
dc.creatorVillares, Joao
dc.creatorCosta, Isabela-Bazzo
dc.creatorTurecki, Gustavo
dc.creatorLinde, Sandra Aparecido [UNESP]
dc.creatorSmith, Marilia Cardoso
dc.creatorPayao, Spencer-Luiz
dc.date2015-03-18T15:56:20Z
dc.date2015-03-18T15:56:20Z
dc.date2014-01-01
dc.date.accessioned2023-09-12T03:13:08Z
dc.date.available2023-09-12T03:13:08Z
dc.identifierhttp://dx.doi.org/10.3233/JAD-140033
dc.identifierJournal Of Alzheimers Disease. Amsterdam: Ios Press, v. 42, n. 3, p. 757-760, 2014.
dc.identifier1387-2877
dc.identifierhttp://hdl.handle.net/11449/117499
dc.identifier10.3233/JAD-140033
dc.identifierWOS:000342237000004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766983
dc.descriptionPresenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-beta peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniversidade do Sagrado Coracao de Bauru
dc.descriptionFaculdade de Medicina de Marilia (FAMEMA)
dc.descriptionFac Med Marilia, Sao Paulo, Brazil
dc.descriptionUniv Sagrado Coracao, Sao Paulo, Brazil
dc.descriptionUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.descriptionDouglas Hosp, Brain Bank, Montreal, PQ, Canada
dc.descriptionUniv Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo, Brazil
dc.descriptionFAPESP: 09/10777-7
dc.descriptionFAPESP: 09/15857-9
dc.format757-760
dc.languageeng
dc.publisherIos Press
dc.relationJournal Of Alzheimers Disease
dc.relation3.476
dc.relation1,635
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlzheimer's disease
dc.subjectbrain
dc.subjectgene expression
dc.subjectpresenilin-1
dc.subjectpresenilin-2
dc.subjectgamma-secretase
dc.titlePSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach
dc.typeArtigo


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