Artigo
Nonalcoholic fatty liver disease and metabolic syndrome in postmenopausal women
Registro en:
Gynecological Endocrinology. New York: Informa Healthcare, v. 30, n. 5, p. 325-329, 2014.
0951-3590
10.3109/09513590.2013.875992
WOS:000334743400001
4155170574788417
Autor
Rodrigues, Marcio H. [UNESP]
Bruno, Anderson S. [UNESP]
Nahas-Neto, Jorge [UNESP]
Santos, Maria Emilia S.
Nahás, Eliana Aguiar Petri [UNESP]
Resumen
Nonalcoholic fatty liver disease (NAFLD) is considered the most common cause of chronic liver disease in the Western countries. NAFLD includes a spectrum ranging from a simple steatosis to a nonalcoholic steatohepatitis (NASH) which is defined by the presence of inflammatory infiltrate, cellular necrosis, hepatocyte ballooning, and fibrosis and cirrhosis that can eventually develop into hepatocellular carcinoma. Studies emphasize the role of insulin resistance, oxidative stress, pro-inflammatory cytokines, adipokines in the development and progression of NAFLD. It seems to be independently associated with type II diabetes mellitus, increased triglycerides, decreased HDL-cholesterol, abdominal obesity and insulin resistance. These findings are in accordance with the criteria used in the diagnosis of metabolic syndrome (MetS). Here, we will discuss the current knowledge on the epidemiology, pathophysiology and diagnosis of NAFLD and the association of metabolic syndrome in postmenopausal women. Sao Paulo State Univ, Botucatu Med Sch, Dept Gynecol & Obstet, Sao Paulo, Brazil Univ Fed Ouro Preto, Dept Gynecol & Obstet, Ouro Preto, MG, Brazil Univ Fed Sao Joao del Rei, Lab Metab Biochem, Divinopolis, MG, Brazil Sao Paulo State Univ, Botucatu Med Sch, Dept Gynecol & Obstet, Sao Paulo, Brazil