Artículo de revista
Biomarkers for dementia in Latin American countries: gaps and opportunities
Fecha
2022Registro en:
Alzheimer’s Dement. 2023;19:721–735
10.1002/alz.12757
Autor
Parra, Mario A.
Orellana, Paulina
León Rodríguez, Tomás Ignacio
Cabello G., Victoria
Henríquez, Fernando
Gómez, Rodrigo
Avalos, Constanza
Damian, Andrés
Slachevsky Chonchol, Andrea María
Ibañez, Augustín
Zetterberg, Henrik
Tijms, Betty M.
Yokoyama, Jennifer S.
Piña Escudero, Stefanie D.
Cochran, J. Nicholas
Matallana, Diana L.
Acosta, Daisy
Allegri, Ricardo
Arias Suárez, Bianca P.
Barra, Bernardo
Behrens Pellegrino, María Isabel Ofelia
Brucki, Sonia M.D.
Busatto, Geraldo
Caramelli, Paulo
Castro Suarez, Sheila
Contreras, Valeria
Custodio, Nilton
Dansilio, Sergio
De la Cruz Puebla, Myriam
Cruz de Souza, Leonardo
Diaz, Mónica M.
Duque, Lissette
Farías Gontupil, Gonzalo Andrés
Ferreira, Sergio T.
Magrath Guimet, Nahuel
Kmaid, Ana
Lira, David
Lopera, Francisco
Mar Meza, Beatriz
Miotto, Eliane C.
Nitrini, Ricardo
Núñez, Alberto
O’Neill, Santiago
Ochoa, John
Pintado Caipa, Maritza
França Resende, Elisa de Paula
Risacher, Shannon
Rojas, Luz Angela
Sabaj, Valentina
Schilling, Lucas
Sellek, Allis F.
Sosa, Ana
Takada, Leonel T.
Teixeira, Antonio L.
Unaucho Pilalumbo, Martha
Durán Aniotz, Claudia
Institución
Resumen
Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.