Síntese regioespecífica de 1H-pirazolilquinolinas trifluormetil substituídas

Abstract

This work describes the synthesis of a serie of 4-(3-alkyl(aryl)-5-trifluoromethyl-1Hpyrazol- 1-yl)-7-chloroquinolines (6), from the cyclondensation reactions of 1,1,1-trifluoro- 4-methoxy-3-buten-2-ones (4) and 7-chloro-4-hydrazinoquinoline, with isolation of the intermediary pyrazolines 4-[3-alkyl(aryl)-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1Hpirazol- 1-yl]-7-chloroquinolines (5). [...]