info:eu-repo/semantics/article
High frequency of Panton-Valentine leukocidin genes in invasive methicillin-susceptible Staphylococcus aureus strains and the relationship with methicillin-resistant Staphylococcus aureus in Córdoba, Argentina
Autor
Sola, C.
Saka, H.A.
Vindel, A.
Bocco, José Luis
Monterisi, A.
Rocchi, M.
Díaz, E.
Lomberghini, R.
Littvik, A.M.
López, T.
Yudowsky, S.
Carvajal, L.
Culasso, C.
Perlo Morales, O.
Aissa, M.S.
Vilaro, M.
Bongiovanni, M.E.
Mangiaterra, S.
Barbon, S.
Wolff, L.
Vercelli, B.
D'Andrea, E.M.
López, A.
Pino, Gustavo Ariel
Muñoz, V.
Bottiglieri, Marina Teresita
Institución
Resumen
In the study presented here, the genetic characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) strains isolated from patients attending hospitals in the city of Córdoba, Argentina, during 1999-2002 were evaluated to determine their genetic relationship with methicillin-resistant S. aureus (MRSA) clones as part of an effort to control the potential emergence of new epidemic MRSA strains. The results showed there is a high frequency of MSSA strains carrying Panton-Valentine leukocidin genes in invasive infections in Córdoba, Argentina, particularly in those occurring in hospital settings. Panton-Valentine leukocidin genes were found in the genomic background of one clone (ST30-N pulsotype) belonging to a successful internationally distributed MSSA lineage (clonal complex 30), which is closely related to the EMRSA-16 pandemic clone. These genes were also detected in the ancestral clone (ST5-M pulsotype) of the most prevalent MRSA epidemic clone causing healthcare-associated infections in this region, known as the Cordobes/Chilean clone. The molecular characterization of circulating MSSA strains, including the detection of Panton-Valentine leukocidin genes, is thus a useful marker for investigating the evolving epidemiology of hospital- and community-acquired MRSA clones. Fil: Sola, C. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Ciudad Universitaria, Córdoba 5000, Haya de la Torre y M. Allende s/n, Argentina Fil: Saka, H.A. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Ciudad Universitaria, Córdoba 5000, Haya de la Torre y M. Allende s/n, Argentina Fil: Vindel, A. Laboratorio de Enfermedades Infecciosas Nosocomiales, Instituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Madrid 28220, Spain Fil: Bocco, José Luis. Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Ciudad Universitaria, Córdoba 5000, Haya de la Torre y M. Allende s/n, Argentina Fil: Monterisi, A. Hospital Nacional de Clínicas, Argentina Fil: Rocchi, M. Hospital Nacional de Clínicas, Argentina Fil: Díaz, E. Hospital Militar de Córdoba Fil: Lomberghini, R. Hospital Militar de Córdoba Fil: Littvik, A.M. Hospital Rawson, Argentina Fil: López, T. Hospital Rawson, Argentina Fil: Yudowsky, S. Hospital Infantil Fil: Carvajal, L. Hospital de Niños Fil: Culasso, C. Hospital de Niños Fil: Perlo Morales, O. Hospital Córdoba, Argentina Fil: Aissa, M.S. Hospital Córdoba, Argentina Fil: Vilaro, M. Hospital Privado de Córdoba, Argentina Fil: Bongiovanni, M.E.Hospital Italiano de Córdoba, Argentina Fil: Mangiaterra, S. Hospital Italiano de Córdoba, Argentina Fil: Barbon, S. Hospital Italiano de Córdoba, Argentina Fil: Wolff, L. Clinica Privada Velez Sarsfield, Argentina Fil: Vercelli, B. Clinica Privada Velez Sarsfield, Argentina Fil: D'Andrea, E.M. Hospital de Urgencias Fil: López, A. Hospital de Urgencias Fil: Pino, Gustavo Ariel. Hospital San Roque, Argentina Fil: Muñoz, V. Hospital San Roque, Argentina Fil: Bottiglieri, Marina Teresita. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina