info:eu-repo/semantics/article
Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
Registro en:
Pabón A, Blair S, Carmona J, Zuleta M, Saez J. Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae). Pharmazie. 2003 Apr;58(4):263-7.
0031-7144
Autor
Pabón Vidal, Adriana Lucía
Blair Trujillo, Silvia
Zuleta, Margarita
Carmona Fonseca, Jaime
Sáez Vega, Jairo Antonio
Institución
Resumen
ABSTRACT: Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations. COL0007524