Evaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)

dc.creatorPabón Vidal, Adriana Lucía
dc.creatorBlair Trujillo, Silvia
dc.creatorZuleta, Margarita
dc.creatorCarmona Fonseca, Jaime
dc.creatorSáez Vega, Jairo Antonio
dc.date2022-11-13T19:31:26Z
dc.date2022-11-13T19:31:26Z
dc.date2003
dc.date.accessioned2023-08-28T20:29:45Z
dc.date.available2023-08-28T20:29:45Z
dc.identifierPabón A, Blair S, Carmona J, Zuleta M, Saez J. Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae). Pharmazie. 2003 Apr;58(4):263-7.
dc.identifier0031-7144
dc.identifierhttps://hdl.handle.net/10495/32014
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8480076
dc.descriptionABSTRACT: Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.
dc.descriptionCOL0007524
dc.format5
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherGovi-Verlag Pharmazautischer Verlag
dc.publisherGrupo Malaria
dc.publisherBerlín, Alemania
dc.relationPharmazie.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAcetilación
dc.subjectAcetylation
dc.subjectSustitución de Aminoácidos
dc.subjectAmino Acid Substitution
dc.subjectAntimaláricos
dc.subjectAntimalarials
dc.subjectPruebas de Mutagenicidad
dc.subjectMutagenicity Tests
dc.subjectExtractos Vegetales
dc.subjectPlant Extracts
dc.subjectSalmonella typhimurium
dc.subjectCompuestos de Espiro
dc.subjectSpiro Compounds
dc.titleEvaluation of the Mutagenicity of Antimalarial products isolated from Solanum nudum (Solanaceae)
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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