info:eu-repo/semantics/article
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
Registro en:
Barea, C., Pabón, A., Pérez-Silanes, S., Galiano, S., Gonzalez, G., Monge, A., ... & Aldana, I. (2013). New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules, 18(4), 4718-4727. DOI:10.3390/molecules18044718
1420-3049
10.3390/molecules18044718
Autor
Barea, Carlos
Pabón Vidal, Adriana Lucía
Pérez Silanes, Silvia
Galiano, Silvia
González, Germán
Monge, Antonio
Deharo, Eric
Aldana Moraza, Ignacio
Institución
Resumen
ABSTARCT: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position