New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities

dc.creatorBarea, Carlos
dc.creatorPabón Vidal, Adriana Lucía
dc.creatorPérez Silanes, Silvia
dc.creatorGaliano, Silvia
dc.creatorGonzález, Germán
dc.creatorMonge, Antonio
dc.creatorDeharo, Eric
dc.creatorAldana Moraza, Ignacio
dc.date2017-08-09T14:22:30Z
dc.date2017-08-09T14:22:30Z
dc.date2013
dc.date.accessioned2023-08-28T20:08:00Z
dc.date.available2023-08-28T20:08:00Z
dc.identifierBarea, C., Pabón, A., Pérez-Silanes, S., Galiano, S., Gonzalez, G., Monge, A., ... & Aldana, I. (2013). New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules, 18(4), 4718-4727. DOI:10.3390/molecules18044718
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/10495/7889
dc.identifier10.3390/molecules18044718
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8474366
dc.descriptionABSTARCT: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position
dc.format9
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherBoard
dc.publisherGrupo Malaria
dc.publisherSuiza
dc.relationMolecules
dc.rightsAtribución 2.5
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectAntiplasmodial
dc.subjectLeishmanicidal
dc.subjectQuinoxaline
dc.titleNew amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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