Capitulo de libro
Immune Evasion by Herpes Simplex Viruses
Herpesviruses
Registro en:
1140011
978-9535126102
Autor
Retamal-Díaz, Angello Ricardo
Tognarelli-Torres, Eduardo Ignacio
Kalergis, Alexis M
Bueno, Susan M
González-Muñoz, Pablo Alberto
Ongradi, Jozsef
Institución
Resumen
Infection with herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) is extremely
frequent in the human population, as well as recurrent reactivations due to lifelong
infection. Infection and persistence of HSVs within healthy individuals likely results as
a consequence of numerous molecular determinants evolved by these pathogens to
escape both immediate and long-term host antiviral mechanisms. Indeed, HSVs harbor
an arsenal of proteins that confer them stealth by negatively modulating immune
function. Consequently, these viruses perpetuate within the host, altogether silently
shedding onto other individuals. In this chapter, we discuss HSV determinants that
interfere with cellular antiviral factors, as well as viral determinants that hamper innate
and adaptive immune components intended to control such microbes. The identification
of HSV evasion molecules that modulate the immune system, as well as the
understanding of their mechanisms of action, should facilitate the design of novel
prophylactic and therapeutic strategies to overcome infection and disease elicited by
these viruses. This chapter is intended to provide an overview of the evasion mechanisms
evolved by herpes simplex viruses to escape numerous host antiviral mediators.
Keywords: immune evasion, innate immunity, adaptive immunity, antiviral response FONDECYT FONDECYT