submittedVersion
Ácido tranexámico y su aplicación en cirugía oral. Revisión sistemática
Fecha
2023-07-19Autor
Armijos Idrovo, Silvana Graciela
Pacheco Carabajo, Luis Adrian
Institución
Resumen
Background: Tranexamic acid (TXA) is a synthetic analogue of lysine, which inhibits
fibrinolysis by reducing the conversion of plasminogen into plasmin, thereby promoting the
preservation of the clot formed in the operated area and reducing the risk of bleeding. It is
eventually used as a complement in oral surgery. Purpose: To analyze the evidence on the
effectiveness in hemostasis, appropriate dose, safety margin, benefits, and postoperative
evolution of TXA used in oral surgery. Methods: The systematic review was structured from a
search tree (PubMed, Google Scholar, ProQuest, and Scopus), with the keywords and
Boolean connector: Tranexamic Acid AND Oral Surgery. The search was limited to the
English, Portuguese, and Spanish languages; open-access articles; systematic reviews,
meta-analyses, randomized clinical trials, and case reports. We established a secondary
selection based on the title and abstract of the articles according to the purpose of the study.
Findings: The literature reports an efficacy of 80 % of TXA in reducing bleeding risk during
and after surgical procedures, which optimizes the procedures. Conclusions: Topical or
intravenous TXA in doses not exceeding 20 mg has proven to be effective to reduce the risk
of bleeding in oral surgery.