Phospholamban: a tiny protein with a prominent role in the regulation of cardiac  relaxation and contractility

Mattiazzi, Alicia Ramona; Mundiña-Weilenmann, Cecilia; Vittone, Leticia

Articulo

Registro en:

http://sedici.unlp.edu.ar/handle/10915/104650

http://hdl.handle.net/11336/61840

issn:1669-5410

https://repositorioslatinoamericanos.uchile.cl/handle/2250/7445102

Autor

Mattiazzi, Alicia Ramona

Mundiña-Weilenmann, Cecilia

Vittone, Leticia

Institución

Universidad Nacional de La Plata (Argentina)

Resumen

Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.

Centro de Investigaciones Cardiovasculares

Materias

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