Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility

dc.creatorMattiazzi, Alicia Ramona
dc.creatorMundiña-Weilenmann, Cecilia
dc.creatorVittone, Leticia
dc.date2010-11
dc.date2020-09-15T14:18:51Z
dc.date.accessioned2023-07-14T21:58:12Z
dc.date.available2023-07-14T21:58:12Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/104650
dc.identifierhttp://hdl.handle.net/11336/61840
dc.identifierissn:1669-5410
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7445102
dc.descriptionPhospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
dc.descriptionCentro de Investigaciones Cardiovasculares
dc.formatapplication/pdf
dc.format8-17
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectPhospholamban
dc.subjectCardiac relaxation
dc.subjectContractility
dc.titlePhospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
dc.typeArticulo
dc.typeArticulo


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