Article
Effect of Ginkgo biloba extract EGb 761 on the nonspecific and humoral immune responses in a hypothalamic-pituitary-adrenal axis activation model
Fecha
2011Autor
Ramos-Zavala, M.G.
Gonzalez-Ortiz, M.
Martinez-Abundis, E.
Robles-Cervantes, J.A.
Gonzalez-Lopez, R.
Santiago-Hernandez, N.J.
Institución
Resumen
OBJECTIVE - To assess the effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - A randomized, double-blind, placebo-controlled clinical trial was carried out in 40 drug-naive adult patients with type 2 diabetes. A metabolic profile including interleukin (IL)-1?, tumor necrosis factor-a, IL-6, and fasting insulin levelswas carried out before the intervention and 2months afterward. A hyperglycemic-hyperinsulinemic clamp technique was performed to assess the phases of insulin secretion and insulin sensitivity. After randomization, 20 patients received diacerein (50mg once daily) for the first 15 days and twice daily for 45 additional days. The remaining patients received placebo. Intra- and intergroup differences were calculated by Wilcoxon signed rank and Mann-Whitney U tests. RESULTS-Therewere significant increases in first (102 63 vs. 130 75 pmol/L; P<0.01), late (219 111 vs. 280 135 pmol/L; P<0.01), and total insulin (178691 vs. 216699pmol/L; P<0.01) secretionswithout changes in insulin sensitivity after diacerein administration. There were significant decreases in fasting glucose (7.9 1.4 vs. 6.8 1.0mmol/L; P<0.01) and in A1C levels (8.3 1.0 vs. 7.0 0.8%; P < 0.001) after diacerein administration. There were no significant changes after placebo administration in the above-mentioned evaluations. CONCLUSIONS - Insulin secretion increased and metabolic control improved after diacerein administration in drug-naive patients with type 2 diabetes. " 2011 by the American Diabetes Association.",,,,,,"10.2337/dc11-0357",,,"http://hdl.handle.net/20.500.12104/40923","http://www.scopus.com/inward/record.url?eid=2-s2.0-80054701972&partnerID=40&md5=490c7769894124ae564cc6003c1000d2 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=21610123",,,,,,"7",,"Diabetes Care",,"1591 1594",,"34",,"Scopus WOS MEDLINE",,,,,,"Index Medicus;Adult;Anthraquinones/tu [Therapeutic Use];Blood Glucose/me [Metabolism];Diabetes Mellitus, Type 2/dt [Drug Therapy];Fasting;Female;Hemoglobin A, Glycosylated/me [Metabolism];Humans;Insulin/se [Secretion];Interleukin-1beta/me [Metabolism];Interleukin-6/me [Metabolism];Male;Middle Aged;Obesity/dt [Drug Therapy];Overweight/dt [Drug Therapy];Tumor Necrosis Factor-alpha/me [Metabolism]",,,,,,"Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: A randomized clinical trial",,"Article"
"42722","123456789/35008",,"Villaseñor-García, M.M., Lab. Inmunofarmacologia Prod. Nat., Div. de Medicina Molecular CIBO-IMSS, Guadalajara, Jalisco, Mexico, Dpto. de Farmacobiología, CUCEI Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Centro de Investigación, Biomédica de Occidente, IMSS, Sierra Mojada No. 800, C.P. 44340 Guadalajara, Jalisco, Mexico; Lozoya, X., Laboratorio de Plantas Medicinales, U. Invest. en Enferm. Neurologicas, C.M.N. Siglo XXI, México, D.F., Mexico; Osuna-Torres, L., Laboratorio de Biotecnología, Ctro. de Invest. Biomedica del Sur, IMSS, Cuernavaca, Morelos, Mexico; Viveros-Paredes, J.M., Lab. Inmunofarmacologia Prod. Nat., Div. de Medicina Molecular CIBO-IMSS, Guadalajara, Jalisco, Mexico; Sandoval-Ramírez, L., Laboratorio de Bioquímica IV, Div. de Genética Humana, IMSS, Guadalajara, Jalisco, Mexico; Puebla-Pérez, A.M., Lab. Inmunofarmacologia Prod. Nat., Div. de Medicina Molecular CIBO-IMSS, Guadalajara, Jalisco, Mexico, Dpto. de Farmacobiología, CUCEI Universidad de Guadalajara, Guadalajara, Jalisco, Mexico",,"Villasenor-García, M.M. Lozoya, X. Osuna-Torres, L. Viveros-Paredes, J.M. Sandoval-Ramirez, L. Puebla-Perez, A.M.",,"2004",,"We evaluated the immune response of healthy control and stressed Wistar rats submitted to hypothalamic-pituitary-adrenal (HPA) axis activation. Rats were treated with Ginkgo biloba extract (EGb 761) orally (100 mg/kg per day for 7 days). EGb 761 stimulated the digestion index of peritoneal and alveolar macrophages (PM and AM) of stressed rats. Likewise, the cellular immune response measured using the delayed-type hypersensitivity response to sheep red blood cells (SRBC) and the humoral immune response (measured through an anti-SRBC response), were also restored in stressed rats. Thus, this G. biloba extract possesses immunostimulatory activity in addition to its broad spectrum of pharmacological effects. " 2004 Elsevier B.V. All rights reserved.