[Minor phenotypic variants in patients with acute lymphoblastic leukemia from west Mexico]

Abstract

The present document has been prepared by a group of experts, members of Cardiology, Endocrinology, Internal Medicine, Nephrology and Diabetes societies of Latin American countries, to serve as a guide to physicians taking care of patients with diabetes, hypertension and comorbidities or complications of both conditions. Although the concept of metabolic syndrome is currently disputed, the higher prevalence in Latin America of that cluster of metabolic alterations has suggested that metabolic syndrome is useful nosography entity in the context of Latin American medicine. Therefore, in the present document, particular attention is paid to this syndrome in order to alert physicians on a particular high- risk population, usually underestimated and undertreated. These recommendations results from presentation and debates by discussion panels during a 2-day conference held in Bucaramanga, in October 2012, and all the participants have approved the final conclusions. The authors acknowledge that the publication and diffusion of guidelines do not suffice to achieve the recommended changes in diagnostic or therapeutic strategies, and plan suitable interventions overcoming both physicians and patients from effectively adhering to guideline recommendations. Copyright ?" 2013 Elsevier Espana, S.L. y SEA. All rights reserved.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; [Spanish]; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: 9208512; Keyword Heading: Arterial hypertension Consenso latinoamericano Diabetes Hipertension arterial Latin American consensus Metabolic syndrome Sindrome metabolico; Publisher Item Identifier: S0214-9168(13)00126-5; Entry Date: 20150413",,,,"10.1016/j.arteri.2013.11.008",,"1578-1879; 0214-9168","http://hdl.handle.net/20.500.12104/37213","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24365579",,"Spanish",,,,"2",,"Clinica e Investigacion en Arteriosclerosis",,"85

103",,"26",,"MEDLINE",,,,,,"Index Medicus;Consensus;Diabetes Mellitus, Type 2/co [Complications];Diabetes Mellitus, Type 2/ep [Epidemiology];Diabetes Mellitus, Type 2/th [Therapy];Humans;Hypertension/co [Complications];Hypertension/ep [Epidemiology];Hypertension/th [Therapy];Latin America/ep [Epidemiology];Metabolic Syndrome X/co [Complications];Metabolic Syndrome X/ep [Epidemiology];Metabolic Syndrome X/th [Therapy];Practice Guidelines as Topic;Prevalence;Risk Factors",,,,,"Consenso latinoamericano de hipertension en pacientes con diabetes tipo 2 y sindrome metabolico.","[Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome]",,"Journal Article" "35701","123456789/35008",,"Univ Guadalajara, Guadalajara 44430, Jalisco, Mexico",,"Montiel, T

Matute, E

Zarabozo, D",,"2000",,,,,,,,,,"0020-7594","http://hdl.handle.net/20.500.12104/35768",,,"English",,"PSYCHOLOGY PRESS",,"03-abr",,"INTERNATIONAL JOURNAL OF PSYCHOLOGY",,"336

336",,"35",,"WOS",,,,,,,,,,,,"Phonological awareness and reading in Spanish speaking children",,"Meeting Abstract" "35715","123456789/35008",,"[Macias, Jose; Armendariz-Borunda, Juan] Univ Guadalajara, Inst Biol Mol & Terapia Genica, Guadalajara 44430, Jalisco, Mexico; [Macias, Jose; Caligiuri, Alessandra; Pinzani, Massimo] Univ Florence, Dipartimento Med Interna, Florence, Italy; [Novo, Erica; Parola, Maurizio] Univ Turin, Dipartimento Med & Oncol Sperimentale, Turin, Italy",,"Macias, J

Caligiuri, A

Novo, E

Parola, M

Pinzani, M

Armendariz-Borunda, J",,"2011",,,,,,,,,,"0270-9139","http://hdl.handle.net/20.500.12104/35782",,,"English",,"WILEY-BLACKWELL",,,,"HEPATOLOGY",,"785A

785A",,"54",,"WOS",,,,,,,,,,,,"PIRFENIDONE REDUCES FIBROGENIC AND INFLAMMATORY EFFECTS INDUCED BY OXIDATIVE STRESS THROUGH NRF2 ACTIVATION IN HUMAN HEPATIC STELLATE CELLS",,"Meeting Abstract" "35727","123456789/35008",,,,"MORRIS, SD",,"1992",,,,,,,,"10.2307/166149",,"0022-1937","http://hdl.handle.net/20.500.12104/35794",,,"English",,"UNIV MIAMI",,"1",,"JOURNAL OF INTERAMERICAN STUDIES AND WORLD AFFAIRS",,"27

57",,"34",,"WOS",,,,,,,,,,,,"POLITICAL REFORMISM IN MEXICO - SALINAS AT THE BRINK",,"Article" "39009","123456789/35008",,"Estrada-Padilla,S A. Instituto de Genetica Humana <<Dr. Enrique Corona Rivera>>, Departamento de Biologia Molecular y Genomica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. Corona-Rivera,J R. Instituto de Genetica Humana <<Dr. Enrique Corona Rivera>>, Departamento de Biologia Molecular y Genomica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Servicio de Genetica, Division de Pediatria, Hospital Civil de Guadalajara <<Dr. Juan I. Menchaca>>, Guadalajara, Jalisco, Mexico. Electronic address: rocorona@cucs.udg.mx. Sanchez-Zubieta,F. Unidad de Citogenetica, Servicio de Hemato-Oncologia, Division de Pediatria, Hospital Civil de Guadalajara <<Dr. Juan I. Menchaca>>, Guadalajara, Jalisco, Mexico; Instituto de Investigacion en Cancer Infantil y de la Adolescencia, Departamento de Reproduccion Humana, Crecimiento y Desarrollo Infantil, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. Bobadilla-Morales,L. Unidad de Citogenetica, Servicio de Hemato-Oncologia, Division de Pediatria, Hospital Civil de Guadalajara <<Dr. Juan I. Menchaca>>, Guadalajara, Jalisco, Mexico; Instituto de Investigacion en Cancer Infantil y de la Adolescencia, Departamento de Reproduccion Humana, Crecimiento y Desarrollo Infantil, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. Corona-Rivera,A. Unidad de Citogenetica, Servicio de Hemato-Oncologia, Division de Pediatria, Hospital Civil de Guadalajara <<Dr. Juan I. Menchaca>>, Guadalajara, Jalisco, Mexico; Instituto de Investigacion en Cancer Infantil y de la Adolescencia, Departamento de Reproduccion Humana, Crecimiento y Desarrollo Infantil, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.",,"Estrada-Padilla SA

Corona-Rivera JR

Sanchez-Zubieta F

Bobadilla-Morales L

Corona-Rivera A",,"2015",,"INTRODUCTION: Acute lymphoblastic leukemia (ALL) has been associated with an excess of minor phenotypic variants (MPV), including common variants and minor anomalies, indicative of an altered phenogenesis. The objective of the study was to determine the association between MPV and ALL. PATIENTS AND METHODS: In a hospital based case-control study, we studied 120 children with ALL (including standard and high risk) and 120 healthy children as a control group, matched for age and sex, seen in the Hospital Civil de Guadalajara Dr. Juan I. Menchaca (Guadalajara, Mexico). In both groups, 28 anthropometric measurements were made, as well as a systematic search for 405 MPV, through a physical examination. Adjusted odds ratio was estimated (aOR) with its intervening variables by logistic regression. The confidence interval was 95% (95%CI). RESULTS: Anthropometric signs associated with ALL were: long upper segment (aOR= 2.19, 95%CI: 1.01-4.76), broad jaw (aOR= 2.62, 95%CI: 1.29-5.30), narrow ears (aOR= 6.22, 95%CI: 2.60-14.85), and increase in internipple distance (aOR= 2.53, 95%CI: 1.07-5.98). The hypoplasia mesofacial, broad forehead, small nose, short columella, narrow ears, telethelia, Sydney crease (SC), Greek type feet and cafe-au-lait spots (CALS), had a 3 to 17 times higher frequency in children with ALL. By number, an association was found from >4 MPV (aOR= 2.14, 95%CI: 1.25-3.66, P=.004). CONCLUSIONS: From >4 MPV, an association was found with ALL, suggesting prenatal factors in phenogenesis and leukemogenesis. CALS and SC were confirmed as MPV in children with ALL.Copyright ?" 2013 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved.