Role of corpus callosum in interhemispheric coherent activity during sleep

Abstract

This paper is focused on the experimental implementation of a robust control scheme for the regulation of volatile fatty acids (VFA) in continuous anaerobic digestion processes. The robust scheme is made of an output feedback control, and an extended Luenberger observer is used to estimate the uncertain terms of the process (i.e., influent concentration and process kinetics). The control scheme is implemented in a pilot plant up-flow fixed-bed reactor that is treating industrial wine distillery wastewater. The performance of the robust scheme is tested over a period of 36 days, under different set-point values and several uncertain scenarios, including model mismatch, badly known parameters, and load disturbances. Experimental results show that the VFA concentration can be effectively regulated over a wide range of operating conditions. In addition, it is shown that the control scheme has a structure that improves its performance in the presence of noisy measurements and control input saturations. " 2008 American Chemical Society.",,,,,,"10.1021/ie800256e",,,"http://hdl.handle.net/20.500.12104/44299","http://www.scopus.com/inward/record.url?eid=2-s2.0-54949101656&partnerID=40&md5=f1d20cb3444cd9ceecff9c38fbe82ff7

http://dx.doi.org/10.1021/ie800256e",,,,,,"20",,"Industrial and Engineering Chemistry Research",,"7715

7720",,"47",,"Scopus

ChemAbsS

WOS",,,,,,,,,,,,"Robust control of volatile fatty acids in anaerobic digestion processes",,"Article" "46102","123456789/35008","Folch, J., Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C./St. Llorenç 21, 43201 Reus, Tarragona, Spain; Junyent, F., Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Nucli Universitari de Pedralbes, Barcelona 08028, Spain, Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C./St. Llorenç 21, 43201 Reus, Tarragona, Spain; Verdaguer, E., Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Auladell, C., Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Pizarro, J.G., Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Nucli Universitari de Pedralbes, Barcelona 08028, Spain; Beas-Zarate, C., Departamento de Biología Celular y Molecular, C.U.C.B.A, Instituto Mexicano Del Seguro Social (IMSS), Sierra Mojada 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Pallàs, M., Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Nucli Universitari de Pedralbes, Barcelona 08028, Spain; Camins, A., Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Nucli Universitari de Pedralbes, Barcelona 08028, Spain

Beas-Zárate, Carlos., Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias",,"Folch, J.

Junyent, F.

Verdaguer, E.

Auladell, C.

Pizarro, J.G.

Beas-Zárate, Carlos

Pallas, M.

Camins, A.",,"2012",,"Currently, there is no effective treatment for neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Thus, a major focus of neuroscience research is to examine the mechanisms involved in neuronal loss in order to identify potential drug targets. Recent results indicate that DNA damage and re-entry into the cell cycle may constitute a common pathway in apoptosis in neurological diseases. The role of the cell cycle in such disorders is supported by data on the brain of patients who showed an increase in cell-cycle protein expression. Indeed, studies performed in neuronal cell preparations indicate that oxidative stress could be the main mechanism responsible for cell cycle re-entry. DNA damage and repair after oxidative stress may activate the enzyme ataxia telangiectasia mutated, which is a cell-cycle regulator. Once the cell cycle is activated, the increase in the expression of transcription factor E2F-1 could induce neuronal apoptosis. Furthermore, the potential routes involved in E2F-1 induced apoptosis could be p53-dependent or p53-independent. Under this E2F-1 hypothesis of cell death, multiple mitochondria-dependent pathways may be activated, including caspase and caspase-independent signaling cascades. Finally, given that cyclin-dependent kinase inhibitory drugs have neuroprotective and anti-apoptotic effects in experimental models, their potential application for the treatment of neurological disorders should be taken into account. © 2011 Springer Science+Business Media, LLC.",,,,,,"10.1007/s12640-011-9277-4",,,,"http://www.scopus.com/inward/record.url?eid=2-s2.0-84865403573&partnerID=40&md5=6685246a3988bdb40fb7a08af4d39840

http://hdl.handle.net/20.500.12104/44323",,,,,,"3",,"Neurotoxicity Research",,"195

207",,"22",,"Scopus

WOS",,,,,,"Alzheimer's disease; CDK5; Cyclin-dependent kinases; E2F-1; P53; Parkinson's disease",,,,"Role of cell cycle re-entry in neurons: A common apoptotic mechanism of neuronal cell death",,,,"Review", "46143","123456789/35008",,"Ramírez-Gaytán, A., Departamento de Ciencias Computaciónales, Centro Universitario de Ciencias Exactas e Ingeniería (CUCEI) de la, Universidad de Guadalajara, Boulevard Marcelino García Barragán # 1421, CP. 44430, Guadalajara, Jalisco, Mexico; Aguirre, J., Instituto de Ingeniería, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacan 04510, Mexico DF, Mexico; Jaimes, M.A., Instituto de Ingeniería, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacan 04510, Mexico DF, Mexico; Huérfano, V., Puerto Rico Seismic Network, Department of Geology, University of Puerto Rico, Residencie 2a Mayagüez R. 9000, 00680, Puerto Rico",,"Ramirez-Gaytan, A.

Aguirre, J.

Jaimes, M.A.

Huerfano, V.",,"2014",,"Seven slip models currently available from kinematic inversions, derived from near-source strong-motion and teleseismic body waves in the 0-1.25 Hz frequency range from Mexico's subduction zone, are used to estimate source-scaling relationships applicable to the region. Our results are compared with existing scaling relations for subduction environments. The relationships for the rupture area of our results are closer to those of Somerville et al. (2002) than to any other, but, like the others, they have smaller areas than predicted by Somerville et al. (2002). Concerning the combined area of asperities, Murotani et al. (2008) and our results predict smaller areas than those obtained by Somerville et al. (2002). Concerning the area of largest asperity, the relationships obtained in this study are slightly smaller than those described by Somerville et al. (2002); this is a consistent result with the relationships of total rupture area and combined area of asperities. In general, the error estimates for the constrained equations derived in this study in all cases are smaller than those relationships compared here. This might suggest that the expressions obtained in this study could be appropriate for the simulations of strong ground motion for a specific scenario of earthquake slip in the region. Also, these results could be an indication that the relationships vary depending on a specific subduction tectonic region. On the other hand, Aguirre and Irikura (2007) estimated the source area for 31 Mexican earthquakes using corner frequencies; these areas show close resemblance with those predicted by the relationships derived in this study. Based on these findings, an important implication is that two different methodologies to determine the total area of asperities based on either low- or high-frequency data generate similar results.",,,,,,"10.1785/0120130041",,,"http://hdl.handle.net/20.500.12104/44364","http://www.scopus.com/inward/record.url?eid=2-s2.0-84897546948&partnerID=40&md5=b94003e2fc937aa045d71d6056961533",,,,,,"2",,"Bulletin of the Seismological Society of America",,"840

854",,"104",,"Scopus

WOS",,,,,,,,,,,,"Scaling relationships of source parameters of Mw 6.9-8.1 earthquakes in the cocos-rivera-north american subduction zone",,"Article" "46103","123456789/35008",,"Corsi-Cabrera, M., Facultad de Psicología, Posgrado, Universidad Nacional Autónoma de México, México City, Mexico; Ondarza, R., Instituto Nacional de Neurología y Neurocirugía MVS, Mexico, DF, Mexico; Martínez-Gutiérrez, V., Facultad de Psicología, Posgrado, Universidad Nacional Autónoma de México, México City, Mexico; Río-Portilla, Y.d., Facultad de Psicología, Posgrado, Universidad Nacional Autónoma de México, México City, Mexico; Guevara, M.A., Instituto de Neurociencias, Universidad de Guadalajara, Jalisco, Mexico; Ramos-Loyo, J., Instituto de Neurociencias, Universidad de Guadalajara, Jalisco, Mexico",,"Corsi-Cabrera, M.

Ondarza, R.

Martinez-Gutierrez, V.

Rio-Portilla, Y.d.

Guevara, M.A.

Ramos-Loyo, J.",,"2006",,"Objective: To investigate to what extent the increase in interhemispheric coherent activity observed from wakefulness to sleep depends on the integrity of the corpus callosum (CC). Methods: Interhemispheric coherent activity was analyzed in two epileptic patients selected for callosotomy because of multifocal refractory epilepsy, before and 4 months after callosotomy. One patient underwent complete callosotomy and another was subjected to callosotomy of the anterior 2/3, which offered the possibility of comparing the role of the CC in the coherent activity increase from wakefulness to sleep, between anterior regions with interrupted CC communication (in the two patients) and posterior regions with intact communication (in one of them). Results were compared with a group of normal subjects. Results: Both patients showed increased coherent activity from wakefulness to sleep after surgery. Conclusions: Results demonstrate that interhemispheric coherent activity, despite an attenuation after surgery, is higher during SWS than during wakefulness after sectioning the CC; however, they have to be taken with caution because they come from two patients only. Significance: Present results show that the increase in coherent activity during sleep does not depend exclusively on callosal integrity but also on state-dependent influences from sleep-promoting mechanisms, probably spread throughout the thalamo-cortical network. " 2006 International Federation of Clinical Neurophysiology.