Article
Cerebral venous thrombosis in a Mexican multicenter registry of acute cerebrovascular disease: The RENAMEVASC study
Fecha
2012Registro en:
10.1016/j.jstrokecerebrovasdis.2011.01.001
Autor
Cisneros-Mejorado, A.
Sanchez Herrera, D.P.
Institución
Resumen
During capacitation of mammalian sperm intracellular [Ca 2+] and cyclic nucleotides increase, suggesting that CNG channels play a role in the physiology of sperm. Here we study the effect of capacitation, 8Br-cAMP (8-bromoadenosine 3?,5?-cyclic monophosphate) and 8Br-cGMP (8-bromoguanosine 3?,5?-cyclic monophosphate) on the macroscopic ionic currents of mouse sperm, finding the existence of different populations of sperm, in terms of the recorded current and its response to cyclic nucleotides. Our results show that capacitation and cyclic nucleotides increase the ionic current, having a differential sensitivity to cGMP (cyclic guanosine monophosphate) and cAMP (cyclic adenosine monophosphate). Using a specific inhibitor we determine the contribution of CNG channels to macroscopic current and capacitation. " 2011 Elsevier Ltd. All rights reserved.",,,,,,"10.1016/j.febslet.2011.12.006",,,"http://hdl.handle.net/20.500.12104/39957","http://www.scopus.com/inward/record.url?eid=2-s2.0-84855771049&partnerID=40&md5=b8aa30e361e7084fba8f981e24664dcf http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22192355",,,,,,"2",,"FEBS Letters",,"149 153",,"586",,"Scopus WOS MEDLINE",,,,"Index Medicus;8-Bromo Cyclic Adenosine Monophosphate/aa [Analogs & Derivatives];8-Bromo Cyclic Adenosine Monophosphate/pd [Pharmacology];Animals;Cyclic AMP/pd [Pharmacology];Cyclic GMP/aa [Analogs & Derivatives];Cyclic GMP/me [Metabolism];Cyclic GMP/pd [Pharmacology];Cyclic GMP/ph [Physiology];Cyclic Nucleotide-Gated Cation Channels/ag [Agonists];Cyclic Nucleotide-Gated Cation Channels/ai [Antagonists & Inhibitors];Cyclic Nucleotide-Gated Cation Channels/me [Metabolism];Cyclic Nucleotide-Gated Cation Channels/ph [Physiology];Dose-Response Relationship, Drug;Drug Resistance/de [Drug Effects];Male;Membrane Potentials/de [Drug Effects];Mice;Sperm Capacitation/de [Drug Effects];Sperm Capacitation/ph [Physiology];Sperm Capacitation;Spermatozoa/de [Drug Effects];Spermatozoa/ph [Physiology]",,"Capacitation; cGMP; CNG channel; Sperm",,,,,,"CGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation",,"Article"
"41741","123456789/35008",,"Castañeda-Saucedo, M.C., Universidad Autónoma de Chapingo (UACh), Mexico, Mexico, COLPOS, México, Mexico, Centro Universitario Del sur, Universidad de Guadalajara (CUSUR-UDG), Mexico, Mexico, Av. Enrique Arreola Silva #883, Col Centro, Ciudad Guzmán, Jalisco CP. 49000, Mexico; Delgado-Alvarado, A., COLPOS, México, Mexico, Universidad Veracruzana, Mexico, Mexico, University of Sheffield, United Kingdom; Córdova-Téllez, L., COLPOS, México, Mexico, UACh, Mexico, Mexico, Mississippi State University, United States, Iowa State University, EEUU, United States; Tapia-Campos, E., COLPOS, México, Mexico, UACh, Mexico, Mexico, CIATEJ, Jalisco, Mexico; González-Hernández, V., COLPOS, México, Mexico, UACh, Mexico, Mexico, University of Nebraska, United States; Santacruz-Varela, A., COLPOS, México, Mexico, UACh, Mexico, Mexico, Iowa State University, United States; Vázquez-Carrillo, M.G., COLPOS, México, Mexico, UACh, Mexico, Mexico, INIFAP, México, Mexico; García-De Los Santos, G., COLPOS, México, Mexico, UACh, Mexico, Mexico, Oregon State University, United States",,"Castaneda-Saucedo, M.C. Delgado-Alvarado, A. Cordova-Tellez, L. Tapia-Campos, E. Gonzalez-Hernandez, V. Santacruz-Varela, A. Vazquez-Carrillo, M.G. García-De Los Santos, G.",,"2012",,"Changes in the concentration of sucrose, glucose, fructose and starch, in leaves, seeds and pods of Phaseolus vulgaris L. cv 'Otomó' of determinate growth habit, were evaluated under both drought stress and non stress (irrigated) conditions. Plants were submitted to drought stress during the flowering, pod formation and seed filling stages. The stress increased the concentrations of glucose from 18 up to 196% and of fructose from 20 up to 333% in mature leaves, likely due to starch hydrolysis, while showing starch reductions from 17 up to 46% and sucrose reductions from 41 up to 70%. These changes in leaves promoted the sugar exports toward pods and seeds, since their sucrose concentration increased. In the reproductive organs, the concentration of glucose and fructose of stressed plants increased 136 and 138% in pods and 83 and 73% in seeds, respectively. Contrary to the changes registered in leaves, in reproductive tissues the sucrose increased up to 238% in pods and up to 148% in seeds, while the starch became reduced down to 37% in pods and to 21% in seeds. The increase of hexoses in pods and seeds might be explained by in situ starch hydrolysis, whereas the increase in sucrose is probably due to an enhanced synthesis of this sugar for a higher osmotic adjustment.",,,,,,,,,"http://hdl.handle.net/20.500.12104/39962","http://www.scopus.com/inward/record.url?eid=2-s2.0-84860369389&partnerID=40&md5=a91d2be552a38bd250a164ed1ec2cb49",,,,,,"3",,"Interciencia",,"168 175",,"37",,"Scopus WOS",,,,,,"Drought Stress; Fructose; Glucose; Phaseolus vulgaris; Starch; Sucrose",,,,,,"Changes in carbohydrate concentration in leaves, PODS and seeds of dry bean plants under drought stress",,"Article"
"41729","123456789/35008",,"Ruiz-Sandoval, J.L., Department of Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico, Department of Neurosciences, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico; Chiquete, E., Department of Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico; Bañuelos-Becerra, L.J., Department of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico; Torres-Anguiano, C., Department of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico; González-Padilla, C., Department of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico; Arauz, A., Stroke Clinic, Instituto Nacional de Neurología Y Neurocirugía, Mexico City, Mexico, ; León-Jiménez, C., Department of Neurology, Hospital Valentín Gómez Farías, Zapopan, Mexico; Murillo-Bonilla, L.M., Endovascular Therapy, Instituto Panvascular de Occidente, Universidad Autónoma de Guadalajara, Guadalajara, Mexico; Villarreal-Careaga, J., Department of Neurology, Hospital General de Culiacán, Culiacán, Mexico; Barinagarrementería, F., Department of Neurology, Hospital Ángeles Querétaro, Querétaro, Mexico; Cantú-Brito, C., Department of Neurology, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico; Cantú-Brito, C.; Arauz-Góngora, A., Stroke Clinic, Instituto Nacional de Neurología Y Neurocirugía, Mexico City, Mexico, ; Ruiz-Sandoval, J.L.; Villarreal-Careaga, J.; Murillo-Bonilla, L.; Rangel-Guerra, R.; Barinagarrementeria, F.",,"Ruiz-Sandoval, J.L. Chiquete, E. Banuelos-Becerra, L.J. Torres-Anguiano, C. Gonzalez-Padilla, C. Arauz, A. Leon-Jimenez, C. Murillo-Bonilla, L.M. Villarreal-Careaga, J. Barinagarrementeria, F. Cantu-Brito, C. Cantu-Brito, C. Arauz-Gongora, A. Ruiz-Sandoval, J.L. Villarreal-Careaga, J. Murillo-Bonilla, L. Rangel-Guerra, R. Barinagarrementeria, F.",,"2012",,"Background: Cerebral venous thrombosis (CVT) is a rare form of cerebrovascular disease that is usually not mentioned in multicenter registries on all-type acute stroke. We aimed to describe the experience on hospitalized patients with CVT in a Mexican multicenter registry on acute cerebrovascular disease. Methods: CVT patients were selected from the RENAMEVASC registry, which was conducted between 2002 and 2004 in 25 Mexican hospitals. Risk factors, neuroimaging, and 30-day outcome as assessed by the modified Rankin scale (mRS) were analyzed. Results: Among 2000 all-type acute stroke patients, 59 (3%; 95% CI, 2.3-3.8%) had CVT (50 women; female:male ratio, 5:1; median age, 31 years). Puerperium (42%), contraceptive use (18%), and pregnancy (12%) were the main risk factors in women. In 67% of men, CVT was registered as idiopathic, but thrombophilia assessment was suboptimal. Longitudinal superior sinus was the most frequent thrombosis location (78%). Extensive (>5 cm) venous infarction occurred in 36% of patients. Only 81% of patients received anticoagulation since the acute phase, and 3% needed decompressive craniectomy. Mechanical ventilation (13.6%), pneumonia (10.2%) and systemic thromboembolism (8.5%) were the main in-hospital complications. The 30-day case fatality rate was 3% (2 patients; 95% CI, 0.23-12.2%). In a Cox proportional hazards model, only age <40 years was associated with a mRS score of 0 to 2 (functional independence; rate ratio, 3.46; 95% CI, 1.34-8.92). Conclusions: The relative frequency of CVT and the associated in-hospital complications were higher than in other registries. Thrombophilia assessment and acute treatment was suboptimal. Young age is the main determinant of a good short-term outcome. " 2012 by National Stroke Association.