Actin-binding proteins and signalling pathways associated with the formation and maintenance of dendritic spines [participación de las proteínas de unión a la actina y vías de señalización asociadas a la formación y mantenimiento de las espinas dendréticas]

Abstract

Background: Acinetobacter baumannii has evolved from an opportunistic pathogen into a common and persistent nosocomial bacterium capable of causing severe infections during endemic and epidemic periods. Methods: The study period extended from January 1999 to December 2011 and involved patients hospitalized at the Hospital Civil de Guadalajara, Fray Antonio Alcalde, Jalisco, Mexico. From each patient, a single isolate was obtained, and a total of 3,680 unique isolates were collected. Susceptibility tests were performed according to the guidelines of the Clinical and Laboratory Standards Institute. Results: A. baumannii has disseminated throughout the Hospital Civil de Guadalajara, Fray Antonio Alcalde, since 1999. A. baumannii isolates obtained from patients treated in the adult intensive care unit represent the majority of the isolates that have been collected. In addition, A. baumannii was isolated from the adult neurosurgical ward and the adult internal medicine ward, and these isolates were frequently obtained from secretions. A persistent decrease in the susceptibility of A. baumannii isolates to meropenem (92% in 1999 to 12% in 2011), imipenem and amikacin has been observed. Conclusions: A. baumannii became an endemic nosocomial pathogen during the study period at the Hospital Civil de Guadalajara, Fray Antonio Alcalde, and has exhibited a persistent decrease in susceptibility to all categories of antimicrobial agents over the past 13 years. Copyright " 2013 S. Karger AG, Basel.",,,,,,"10.1159/000351098",,,"http://hdl.handle.net/20.500.12104/39199","http://www.scopus.com/inward/record.url?eid=2-s2.0-84879757511&partnerID=40&md5=d2d7df412b868946249f7662665d26b8

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23839011",,,,,,"1",,"Chemotherapy",,"57

65",,"59",,"Scopus

WOS

MEDLINE",,,,,,"Acinetobacter baumannii; Antimicrobial susceptibility; Resistance patterns / Index Medicus;Acinetobacter Infections/mi [Microbiology];Acinetobacter baumannii/de [Drug Effects];Acinetobacter baumannii/ip [Isolation & Purification];Amikacin/pd [Pharmacology];Anti-Bacterial Agents/pd [Pharmacology];DNA, Bacterial/an [Analysis];Electrophoresis, Gel, Pulsed-Field;Humans;Imipenem/pd [Pharmacology];Intensive Care Units;Mexico;Microbial Sensitivity Tests;Tertiary Healthcare;Thienamycins/pd [Pharmacology]",,,,,,"Acinetobacter baumannii infections in a tertiary care hospital in mexico over the past 13 years",,"Article" "40980","123456789/35008",,"Podzharov, E., University of Guadalajara, Electromechanical Engineering Department, Av. Revolucion 1500, Puerta 10, Guadalajara, Jalisco, 44430, Mexico, University of Panamericana, Superior School of Engineering, Prolongavion Calz., Circunv. Pte 49, cd. Granja, Guadalajara, Jalisco, Mexico; De La Mora Galvez, F., University of Panamericana, Superior School of Engineering, Prolongavion Calz., Circunv. Pte 49, cd. Granja, Guadalajara, Jalisco, Mexico; Alvarez Sanchez, J.A., University of Guadalajara, Electromechanical Engineering Department, Av. Revolucion 1500, Puerta 10, Guadalajara, Jalisco, 44430, Mexico",,"Podzharov, E.

De La Mora Galvez, F.

Alvarez Sanchez, J.A.",,"2006",,"The statistical energy analysis was used in the acoustical design of an electrical emergency plant to reduce the outdoor noise level. In the past when the plant was working a high annoying noise was heard all over the University camp. At a first glance the principal ways of noise propagation were the open door of the plant which was used for the suction of fresh air and a vast hole in the ceiling which was used for gases outlet. Also, a spectral analysis of the noise inside the plant showed that the dominant frequencies of the noise were in the range of 120-270 Hz. This frequency range is near the critical frequency of the brick walls that is 129 Hz, at which the walls are transparent for noise. A two-block diagram was used for the statistical energy analysis. Two ways of sound transmission was considered through the inlet and outlet holes and through the walls and ceiling. This analysis shows that the exclusion of holes wouldn't be sufficient to reduce noise to an acceptable level in the low frequency range but the increase of noise absorption by the wall coating material. The transmission loss is calculated for different wall coatings and hole areas. A layer of fibreglass of two-inch width is selected to increase the wall absorption coefficient. Special silencers are designed and put at the suction of air and at the outlet of engine gases to reduce the noise propagation through the holes. The noise measurement shows that the noise level is considerably reduced after implementation of these measures. The reduction of noise is 7-8 dB(A), 19 dB(A) and 23 dB(A), inside of the plant, 10 m and 15 m away from the plant, respectively.",,,,,,,,,"http://hdl.handle.net/20.500.12104/39201","http://www.scopus.com/inward/record.url?eid=2-s2.0-84883396244&partnerID=40&md5=2d364eb3472eedb310b57a14e111c78a",,,,,,,,"13th International Congress on Sound and Vibration 2006, ICSV 2006",,"3888

3895",,"5",,"Scopus",,,,,,,,,,,,"Acoustical design of an electrical emergency plant using sea method",,"Conference Paper" "40981","123456789/35008",,"Ibarra-Estrada, M.A., Servicio de Medicina Interna, Hospital Civil de Guadalajara Fray Antonio Alcalde, Mexico; Briseño-Ramírez, J., Servicio de Medicina Interna, Hospital Civil de Guadalajara Fray Antonio Alcalde, Mexico; Chiquete, E., Servicio de Medicina Interna, Hospital Civil de Guadalajara Fray Antonio Alcalde, Mexico; Ruiz-Sandoval, J.L., Servicio de Neurología Y Neurocirugía, Hospital Civil de Guadalajara Fray Antonio Alcalde, Hospital 278, C. P. 44280. Guadalajara, Jalisco, Mexico, Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico",,"Ibarra-Estrada, M.A.

Briseno-Ramirez, J.

Chiquete, E.

Ruiz-Sandoval, J.L.",,"2010",,"In recent years it has been increasingly recognized the presence of acquired neuromuscular disease in the critically ill patient, either as a form of acute myopathy, polyneuropathy or persistent blockade by neuromuscular relaxing agents. Critical illness polyneuropathy (CIP) and myopathy (CIM) are characterized for the presence of weakness, manifested as a quadriparesia, usually flaccid and symmetrical with reduction and/or absence of deep tendon reflexes. Involvement of phrenic nerve, intercostal and accessory respiratory muscles, atrophy and contractile dysfunction of the diaphragm have been described as a cause of delayed mechanical ventilation weaning. Although routine electrophysiological examination sometimes cannot discriminate between patients with CIM and CIP, mainly because they usually coexist, it is useful to rule out other causes of neuromuscular weakness, being able to be practiced before sedation withdrawal. Despite some clinical trials propose as treatment options nutritional interventions with diverse supplements and antioxidants, intravenous immunoglobulin administration or activated protein C, none of them has demonstrated clinical utility. The only management so far is preventive, with emphasis on reducing or discontinuing glucocorticoids and neuromuscular blockers as soon as possible, reaching strict control on blood glucose with insulin, aggressive management of sepsis, early use of spontaneous breathing tests in patients with mechanical ventilation, anticipation of further medical complications and early rehabilitation.",,,,,,,,,"http://hdl.handle.net/20.500.12104/39202","http://www.scopus.com/inward/record.url?eid=2-s2.0-79953177884&partnerID=40&md5=4623c2d33ea712505bdbbcae70c53a7d",,,,,,"4",,"Revista Mexicana de Neurociencia",,"289

295",,"11",,"Scopus",,,,,,"Critical illness patient; Intensive Care Unit; Muscle weakness; Myopathy; Neuromuscular blockade; Polyneuropathy",,,,,,"Acquired weakness in the Intensive Care Unit: Polyneuropathy and myopathy of the critically ill patient [Debilidad adquirida en la Unidad de Cuidados Intensivos: Polineuropatía y miopatía del paciente en estado crítico]",,"Review" "40983","123456789/35008",,"Jasso-Gastinel, C.F., Department of Chemical Engineering, University of Guadalajara, Blvd. Gral. Marcelino García Barragan No.1451, Guadalajara, Jal. C.P. 44430, Mexico; Reyes-Gonzalez, I., Department of Chemical Engineering, University of Guadalajara, Blvd. Gral. Marcelino García Barragan No.1451, Guadalajara, Jal. C.P. 44430, Mexico; Enriquez, S.G., Department of Chemistry, University of Guadalajara, Blvd. Gral. Marcelino García Barragan No.1451, Guadalajara, Jal. C.P. 44430, Mexico; Flores, J., Department of Chemistry, University of Guadalajara, Blvd. Gral. Marcelino García Barragan No.1451, Guadalajara, Jal. C.P. 44430, Mexico; Mijares, E.M., Department of Chemistry, University of Guadalajara, Blvd. Gral. Marcelino García Barragan No.1451, Guadalajara, Jal. C.P. 44430, Mexico",,"Jasso-Gastinel, C.F.

Reyes-Gonzalez, I.

Enriquez, S.G.

Flores, J.

Mijares, E.M.",,"2009",,"Summary: Bioactive cuttlebone Sepia officinalis particles that contain collagen were used to fill poly (methyl methacrylate-co-styrene) bone cements, varying size and concentration of filler particles. Cuttlebone was characterized by X-ray diffraction and plasma atomic emission spectrophotometer. Maximum reaction temperature and cement setting time were determined for composites and reference (copolymer without filler), along with NMR determination of residual monomer concentration. Mechanical properties characterization included stress-strain, bending, compression, fracture toughness and storage modulus tests. Mechanical results for composites filled with 10 and 30% weight of cuttlebone, complied with norm requirements which opens the possibility for using cuttlebone particles as bioactive filler.",,,,,,"10.1002/masy.200950921",,,"http://hdl.handle.net/20.500.12104/39204","http://www.scopus.com/inward/record.url?eid=2-s2.0-70349423641&partnerID=40&md5=9dfddfa925f8bd2a9ae0194435179803",,,,,,"1",,"Macromolecular Symposia",,"159

166",,"283-284",,"Scopus",,,,,,"Acrylic; Bioactive filler; Bone cement; Collagen; Cuttlebone",,,,,,"Acrylic bone cements modified with bioactive filler",,"Article" "40984","123456789/35008",,,,"Silva Moreno, Carlos",,"2000",,,,,,,,,,"1665-0565","http://hdl.handle.net/20.500.12104/39205",,,"Español",,,,"19",,"Espiral. Estudios sobre estado y sociedad",,"51-69",,"7",,"CLASE",,,,,,,,"Sistemas políticos",,,,"Cultura política y partidos en Jalisco",,"journalArticle" "40985","123456789/35008",,"Soria Fregozo, C., Laboratorio de Psicobiología y Biología Molecular, Departamento de Ciencias de la Tierra y de la Vida, Centro Universitario de los Lagos, Universidad de Guadalajara, Guadalajara, Mexico; Pérez Vega, M.I., Laboratorio de Psicobiología y Biología Molecular, Departamento de Ciencias de la Tierra y de la Vida, Centro Universitario de los Lagos, Universidad de Guadalajara, Guadalajara, Mexico",,"Soria Fregozo, C.

Perez Vega, M.I.",,"2012",,"Introduction: Dendritic spines are the main sites of excitatory synaptic contacts. Moreover, they present plastic responses to different stimuli present in synaptic activity or damage, ranging from an increase or decrease in their total number, to redistribution of progenitor dendritic spines, to variations in their size or shape. However, the spines can remain stable for a long time. Background: The use of experimental models has shown that different molecules of the F-actin binding and signalling pathways are closely related to the development, maintenance and plasticity of excitatory synapses, which could affect the number, size and shape of the dendritic spines; these mechanisms affect and depend on the reorganisation of the actin cytoskeleton. Development: It is proposed that the filopodia are precursors of dendritic spines. Drebrin is an F-actin binding protein, and it is responsible for concentrating F-actin and PSD-95 in filopodia that will guide the formation of the new spines. Conclusion: The specific mechanisms of actin regulation are an integral part in the formation, maturing process and plasticity of dendritic spines in association with the various actin cytoskeleton-binding proteins The signalling pathways mediated by small GTPases and the equilibrium between G-actin and F-actin are also involved. " 2011 Sociedad Española de Neurología.